A Study of Efficacy and Safety of Oral Minoxidil in Male Androgenetic Alopecia

August 2025 in “ International Journal of Scientific Research ”

Ankit Yadav, Deepti Saxena, Sachin Aggarwal

oral minoxidil androgenetic alopecia hypertrichosis oedema hypotension skin reactions hair density AGA cardiovascular risks Rogaine male pattern baldness

TLDR Oral minoxidil effectively promotes hair growth in men with hair loss, but caution is needed for older or heart-risk patients.

The study investigated the efficacy and safety of oral minoxidil in treating male androgenetic alopecia, involving 100 males with Grade III–V hair loss. Participants took 5 mg of oral minoxidil daily for 24 weeks, resulting in a significant 20.3% increase in hair density by 28 weeks. While the treatment was generally safe and affordable, side effects such as hypertrichosis (12%), oedema, hypotension, and minor skin reactions were noted. The study concludes that oral minoxidil is effective for hair growth in men with AGA, but caution is recommended for older patients or those with cardiovascular risks.

View this study on worldwidejournals.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community New 2025 study: high dose oral minoxidil (up to 10mg)

in Research/Science 80 upvotes 3 weeks ago

High-dose oral minoxidil (>5 mg/day) can increase hair density in some men with androgenetic alopecia, but side effects like extra body hair and heart issues are common. Gradual dose increase is advised, but adverse effects may lead to discontinuation or dose adjustments.

community The no BS guide to saving your hair without finasteride (improvement in 90% of patients in the study) with a low side effect profile or improvement in 100% of patients but a higher side effect profile and increased dosage. The future is here?

in Minoxidil 92 upvotes 5 years ago

Hair loss treatments, specifically the use of oral minoxidil in combination with micro-needling. Oral minoxidil has been found to improve hair density in 90% of patients with a low side effect profile, but using 5mg per day can result in higher side effects including hypertrichosis and edema. Other treatments mentioned include finasteride and RU58841.

community Androgenetic alopecia - I want your honest opinion

in Female 31 upvotes 2 years ago

A female user's diagnosis of androgenetic alopecia, and the advice shared in response which suggests taking spironolactone and minoxidil together to prevent hair loss.

community Study Shows That Oral Minoxidil Is Not Only Good At Improving Hair But Also Reducing Arterial Stiffness And Preventing Other Health Problems

in Minoxidil 22 upvotes 4 years ago

Oral minoxidil may improve hair growth, reduce arterial stiffness, and prevent other health issues. Some users believe it is an effective treatment despite concerns about its effects on skin and blood.

community 1 month Pyrilutamide. A non responders story to everything.

in Research/Science 218 upvotes 3 years ago

My hairline, I am only 23. This conversation is about a user's experience with treatments for androgenic alopecia, including finasteride, dutasteride, RU, minoxidil, progesterone, melatonin, LLLT, oral minoxidil, and Pyrilutamide. They have tried many treatments over the course of two years without seeing much success, and they are considering getting a hair system as a last resort.

community Is this Better Than Topical Minoxidil? Topical Diazoxide

in Research/Science 6 upvotes 6 months ago

Topical diazoxide may be a promising hair regrowth treatment, especially for those who don't respond to minoxidil, as it activates potassium channels without needing sulfation. It appears safe for topical use, avoiding systemic effects seen in oral use.

Related Research

5 / 5 results

Efficacy and Safety of Oral Minoxidil Compared to Topical Form in Male Pattern Hair Loss

A Study of Efficacy and Safety of Oral Minoxidil in Male Androgenetic Alopecia

Related Community Posts Join

community New 2025 study: high dose oral minoxidil (up to 10mg)

community The no BS guide to saving your hair without finasteride (improvement in 90% of patients in the study) with a low side effect profile or improvement in 100% of patients but a higher side effect profile and increased dosage. The future is here?

community Androgenetic alopecia - I want your honest opinion

community Study Shows That Oral Minoxidil Is Not Only Good At Improving Hair But Also Reducing Arterial Stiffness And Preventing Other Health Problems

community 1 month Pyrilutamide. A non responders story to everything.

community Is this Better Than Topical Minoxidil? Topical Diazoxide

Related Research

research Efficacy and Safety of Oral Minoxidil Compared to Topical Form in Male Pattern Hair Loss

research Contact Dermatitis Caused by Topical Minoxidil: Allergy or Just Irritation

research Tolerance and Safety Profile of Sublingual Minoxidil in the Treatment of Androgenic Alopecia

research Efficacy and Safety of Microneedling Radiofrequency in Patterned Hair Loss

research Efficacy and Safety of Low-Dose Oral Minoxidil in the Management of Androgenetic Alopecia