Efficacy and Safety of Oral Minoxidil Compared to Topical Form in Male Pattern Hair Loss

    Elham Yousefi, Mahshid Sadat Ansari, Safoura Shakoeinejad … Maryam Nasimi
    Studysummary In this randomized controlled trial, oral minoxidil at 2.5 mg daily was more effective than topical minoxidil for increasing hair thickness, counts, and density in men with androgenetic alopecia, demonstrating more significant improvements and better compliance over six months.
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    Research cited in this study 27

    1. Oral Minoxidil Versus Topical Minoxidil for Male Androgenetic Alopecia JAMA dermatology · 2024
    2. Androgenetic Alopecia: A Review Nigerian Postgraduate Medical Journal · 2024
    3. Clinical Efficacy and Safety of Low-Dose Oral Minoxidil Versus Topical Solution in the Improvement of Androgenetic Alopecia: A Randomized Controlled Trial Journal of Cosmetic Dermatology · 2023
    4. Low-Dose Oral Minoxidil for Androgenetic Alopecia Is Not Associated With Clinically Significant Blood-Pressure Changes: A Retrospective Study Journal of The American Academy of Dermatology · 2023
    5. Androgenetic Alopecia: Therapy Update Drugs · 2023
    6. What's New in Therapy for Male Androgenetic Alopecia? American Journal of Clinical Dermatology · 2022
    7. Before-After Study With 24-Hour Ambulatory Blood Pressure Monitoring After the First Dose of 5 Mg Oral Minoxidil Journal of The American Academy of Dermatology · 2022
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    10. Randomized Clinical Trial of Low-Dose Oral Minoxidil for the Treatment of Female Pattern Hair Loss: 0.25 mg Versus 1 mg Journal of The American Academy of Dermatology · 2022
    11. There Is a Positive Dose-Dependent Association Between Low-Dose Oral Minoxidil and Its Efficacy for Androgenetic Alopecia: Findings From a Systematic Review With Meta-Regression Analyses Skin appendage disorders · 2022
    12. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    13. Low-Dose Oral Minoxidil Increases Hair Density and Thickness in Androgenetic Alopecia: A Retrospective Analysis of 60 Patients Journal of The European Academy of Dermatology and Venereology · 2021
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    16. Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients Journal of The American Academy of Dermatology · 2021
    17. Low-Dose Oral Minoxidil for Treating Alopecia: A 3-Year North American Retrospective Case Series Journal of The American Academy of Dermatology · 2020
    18. Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment Dermatology and therapy · 2020
    19. Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety Journal of The American Academy of Dermatology · 2020
    20. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    21. Very-Low-Dose Oral Minoxidil in Male Androgenetic Alopecia: A Study with Quantitative Trichoscopic Documentation Journal of The American Academy of Dermatology · 2019
    22. Minoxidil 1 mg Oral Versus Minoxidil 5% Topical Solution for the Treatment of Female-Pattern Hair Loss: A Randomized Clinical Trial Journal of The American Academy of Dermatology · 2019
    23. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    24. A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2014
    25. A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2007
    26. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    27. Finasteride Increases Anagen Hair in Men with Androgenetic Alopecia British Journal of Dermatology · 2000

    Related research 9

    1. Continued Year-On-Year Improvement in Hair Density With Systemic Minoxidil in Women With Female Pattern Hair Loss: A Case Series Journal of the American Academy of Dermatology · 2025
    2. Oral Finasteride (5 mg and 2 mg) Versus Topical Minoxidil 5% in Female Pattern Hair Loss Clinical Dermatology Review · 2025
    3. Patient-Reported Side Effects of Oral Minoxidil in Treating Female Pattern Hair Loss Journal of Investigative Dermatology · 2024
    4. Hair Loss (Alopecia or Baldness) 2018
    5. Treatments of Hereditary Hair Loss (Alopecia) 2018
    6. Therapy Of Androgenetic Alopecia In Women With Minoxidil Solution Gynäkologische Endokrinologie · 2009
    7. Androgenetic Alopecia in Adolescents PubMed · 2003
    8. Effect of Minoxidil on Hair Growth in Androgenic Alopecia in Women PubMed · 2002
    9. Treatment of Hair Loss The New England Journal of Medicine · 1999