P110 Comparative Efficacy of Low-Dose Oral Minoxidil, Topical Minoxidil, and Platelet-Rich Plasma with Topical Minoxidil in Androgenetic Alopecia: A Randomized Controlled Trial

    June 2024 in “ British Journal of Dermatology ”
    P Janaani, Muthu Sendhil Kumaran, Keshavamurthy Vinay, Hitaishi Mehta, Vinod Sharma
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    TLDR PRP with topical minoxidil is the most effective treatment for increasing hair density in androgenetic alopecia.
    This randomized controlled trial compared the efficacy of low-dose oral minoxidil, topical minoxidil, and platelet-rich plasma (PRP) combined with topical minoxidil in treating androgenetic alopecia (AGA) in 66 male participants. Over 32 weeks, Group 3 (PRP with topical minoxidil) showed the highest increase in terminal hair density, while Group 1 (oral minoxidil) significantly reduced vellus hair density. All treatments led to a significant increase in natural Treg cells and a decrease in inducible Treg cells, with no significant differences between groups. The study supports low-dose oral minoxidil as an effective alternative to topical minoxidil and highlights the benefits of combining PRP with topical minoxidil.
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