Use of Verteporfin with Dermal Wounding to Regenerate New Hair in Androgenetic Alopecia

    September 2025 in “ Journal of Dermatology Research and Therapy ”
    Melissa Toyos, Rolando Toyos, Allison E Toyos, Catherine G Cable
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    TLDR Verteporfin with dermal wounding may boost hair regrowth in thinning areas but not in bald spots.
    This case report explores the off-label use of verteporfin, a medication approved for neovascular macular degeneration, in combination with dermal wounding to promote hair regrowth in two male subjects with androgenetic alopecia. The study involved creating dermal incisions and injecting 25 mg of verteporfin subcutaneously, followed by a topical treatment regimen. Results showed a mean increase in hair density of 63% in traditional donor sites and 38% in thinning areas, with no regrowth in completely bald areas. This novel approach suggests potential for enhancing hair regrowth in thinning areas and strengthening donor sites for future hair transplants.
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      community Verteporfin and Microneedling

      in Treatments 1 year ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community Tropoelastin injections + verteporfin?

      in Research/Science  12 upvotes 2 years ago
      The use of tropoelastin injections and verteporfin for hair transplant recipients to help regrow donor area hairs, as well as research done on tropoelastin injections restoring elastin in scarred heart tissue and skin. There are discussions about why it is taking so long to get cosmetic mass produced tropoelastin injectables on the market.

      community Hair theory Scar tissue and Verteporfin

      in Chat  25 upvotes 1 year ago
      A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

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