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    Glossary Immune Cell

    Immune cells are specialized cells within the immune system that play a crucial role in defending the body against pathogens and foreign substances. In the context of hair loss, certain immune cells, such as T cells, can mistakenly target hair follicles, leading to conditions like alopecia areata, where hair is lost in patches due to an autoimmune response. Key distinguishing characteristics of immune cells include their ability to recognize and respond to antigens, as well as their diverse types, including lymphocytes, macrophages, and dendritic cells, each with specific functions in immune regulation and response. Understanding the role of immune cells in hair biology is essential for developing targeted therapies for autoimmune-related hair loss conditions.

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    1. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007 · 253 citations
    2. Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans Journal of Investigative Dermatology · 2002 · 114 citations
    3. Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases Frontiers in Cell and Developmental Biology · 2019 · 97 citations
    4. Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Journal of Investigative Dermatology · 2013 · 53 citations
    5. Immune cell regulation of the hair cycle Experimental Dermatology · 2020 · 27 citations
    6. RETRACTED: Causal role of immune cells in alopecia areata: A two‐sample Mendelian randomization study Skin Research and Technology · 2024 · 14 citations
    7. Eavesdropping on the conversation between immune cells and the skin epithelium International Immunology · 2019 · 10 citations
    8. Physiological Doses of Red Light Induce IL‐4 Release in Cocultures between Human Keratinocytes and Immune Cells Photochemistry and Photobiology · 2017 · 9 citations
    9. Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing Frontiers in Immunology · 2024 · 7 citations
    10. Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 7 citations
    11. Single‐cell RNA sequencing highlights the role of proinflammatory fibroblasts, vascular endothelial cells, and immune cells in the keloid immune microenvironment International Journal of Dermatology · 2024 · 6 citations
    12. A biopsy-sized 3D skin model with a perifollicular vascular plexus enables studying immune cell trafficking in the skin Biofabrication · 2024 · 6 citations
    13. UVB-induced depletion of donor-derived dendritic cells prevents allograft rejection of immune-privileged hair follicles in humanized mice American journal of transplantation · 2018 · 6 citations
    14. Immune Cells in Cutaneous Wound Healing: A Review of Functional Data from Animal Models International Journal of Molecular Sciences · 2022 · 5 citations
    15. Editorial: Crosstalk: skin cells and immune cells in inflammatory skin diseases Frontiers in Immunology · 2024 · 3 citations
    16. Hair care: Stem cells control immune response during wound repair Immunity · 2024 · 2 citations
    17. A meta-analysis of chemokines in alopecia areata: recruiting immune cells toward the hair follicle Frontiers in Immunology · 2025 · 1 citations
    18. Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration Genes & Diseases · 2025 · 1 citations
    19. LB1031 Immune Cell-Mediated Amplification of Stem Cell Activation in Hairy Melanocytic Nevus via Osteopontin-CD44 Axis Journal of Investigative Dermatology · 2024 · 1 citations
    20. Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation induced tissue damage bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 1 citations
    21. Immune Cell-Targeting Biologics for Alopecia Areata: A New Paradigm in Precision Medicine Skin Appendage Disorders · 2025
    22. Table 2_A meta-analysis of chemokines in alopecia areata: recruiting immune cells toward the hair follicle.docx Figshare · 2025
    23. Table 1_A meta-analysis of chemokines in alopecia areata: recruiting immune cells toward the hair follicle.docx Figshare · 2025
    24. Image 1_A meta-analysis of chemokines in alopecia areata: recruiting immune cells toward the hair follicle.png Figshare · 2025
    25. Exploring the Relationship Between Immune Cells and Non-Scarring Hair Loss: A Mendelian Randomization Study Clinical Cosmetic and Investigational Dermatology · 2024
    26. A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    27. TNC+ fibroblasts involve in skin inflammation via neuro-immune and interacting with T cells Research Square (Research Square) · 2023
    28. Editor's evaluation: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage 2021
    29. 1391 Immune cells may have a role in hair loss process caused by TRPV3 gain-of-function mutation Journal of Investigative Dermatology · 2018
    30. 259 Immunohistochemical insight into the association between the collapse of immune privilege in the sweat gland and syringotropic immune cell infiltrates in collagen diseases Journal of Investigative Dermatology · 2017