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Glossary Cell-Mediated Immunity

immune response involving T cells targeting infected or abnormal cells

Cell-Mediated Immunity (CMI) is a type of immune response that does not involve antibodies but instead relies on the activation of certain immune cells, particularly T cells, to fight off pathogens, infected cells, and cancer cells. This form of immunity is crucial for defending against intracellular pathogens, such as viruses and some bacteria, and plays a significant role in transplant rejection and autoimmune diseases.

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Research

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research Performance of an interferon-γ release assay-based test for cell-mediated immunity to SARS-CoV-2

3 citations , February 2023 in “Frontiers in Immunology”

In this study, researchers reported that a newly developed interferon-γ release assay for cell-mediated immunity to SARS-CoV-2 nucleocapsid peptides demonstrated high sensitivity and specificity, making it a robust tool for routine diagnostic tests and potentially useful in predicting clinical outcomes after pathogen re-exposure.

research Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration

1 citations , January 2025 in “Genes & Diseases”

This review highlights that T cells are crucial in regulating hair follicle regeneration and their disruption can lead to alopecia, providing insights into hair disorders related to T cell immune balance and hair follicle regeneration.

research 0037 Inflammatory implications in female pattern hair loss: unraveling B cell-related immune activation through comparative transcriptome profiling

July 2025 in “Journal of Investigative Dermatology”

Immune system changes may contribute to female pattern hair loss.

research Alopecia Areata

14 citations , January 1985 in “International Journal of Dermatology”

The cause of alopecia areata was unknown, and while various treatments existed, no best treatment was agreed upon.

research Seasonal alopecia areata with atopy

8 citations , October 1989 in “Journal of the American Academy of Dermatology”

In this study, researchers observed that purpuric, telangiectatic, lichenoid balanitis was the most common histologic pattern in cases of chronic pseudoerythroplastic balanitis, suggesting a possible link to lichen aureus.

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Community Join

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community Fats on your Head to Stop Hair Loss?

140 upvotes 2 years ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression

23 upvotes 6 years ago

A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hair follicle cell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.

community The ending of alopecia? Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

63 upvotes 4 years ago

Corticosterone inhibits GAS6, affecting hair follicle stem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.

community Why does this industry still revolve around 5-AR inhibitors?

40 upvotes 5 years ago

Hair loss treatments still rely heavily on minoxidil, finasteride, and RU58841, with little innovation. Future treatments like stem cell therapy and RNA technology show promise but are not yet available.

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Clinics

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Hair Loss Treatments
Immunotherapy Regenerative Medicine - Stem Cell ClinicPuerto Vallarta, Jalisco · MX

Learn

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learn Exosomes

Tiny cell-derived particles offered by clinics as an injectable treatment

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Experts

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Hair Transplant Surgeon
Dr. Amanda Jo Marcellino, MD
Greensboro, NC, United States

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Dr. Amanda Jo Marcellino, MD