Inflammatory Implications In Female Pattern Hair Loss: Unraveling B Cell-Related Immune Activation Through Comparative Transcriptome Profiling

July 2025 in “ Journal of Investigative Dermatology ”

RongSheng Peng, Ming Shi, Hoang Duong Tuan, Yongliang Zhao

female pattern hair loss FPHL B cell-mediated immunity immunoglobulin production CD8+ T cells Tregs immune modulation vertex scalp occipital scalp

TLDR Immune system changes may contribute to female pattern hair loss.

This study on female pattern hair loss (FPHL) involved 10 paired punch biopsies from patients with Sinclair grade 3 or above, focusing on the vertex and occipital scalp. The research identified 71 upregulated and 33 downregulated genes in the affected vertex scalp, with enriched terms related to immune functions such as "immunoglobulin production" and "B cell-mediated immunity." The study found a higher abundance of B cells and CD8+ T cell infiltration in the vertex scalp, while Tregs were reduced. Immune repertoire analysis showed greater diversity in the vertex. These findings suggest immune modulation plays a role in FPHL pathogenesis, potentially guiding future therapeutic strategies.

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