Aberrant B Cell And Cytotoxic T Cell Activation In Female Pattern Hair Loss: A Pilot Comparative Clinico-Transcriptomic Study

December 2025 in “ Journal of Investigative Dermatology ”

Rui Peng, Mai Shi, Yan Li, Jingwen Xue, Eray Yihui Zhou, Yawen Wang, Bingyu Li, Lu Peng, Yixin Gao, Jingxuan Sun, Yi Zhao, Hsiaohan Tuan

female pattern hair loss FPHL B cells cytotoxic T cells immune dysregulation microinflammation male pattern hair loss MPHL immune-related pathways

TLDR Immune system issues may contribute to female pattern hair loss.

This pilot study investigates the immune microenvironment in female pattern hair loss (FPHL) by analyzing matched vertex and occipital scalp samples. The research highlights aberrant activation of B cells and cytotoxic T cells in FPHL, suggesting immune dysregulation as a contributing factor. Although FPHL is traditionally seen as non-inflammatory, this study aligns with emerging evidence of "microinflammation" in male pattern hair loss (MPHL). The findings indicate potential immunological similarities between FPHL and MPHL, despite their clinical differences, and underscore the need for further research into immune-related pathways in FPHL.

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Research cited in this study

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Better then Minoxidil( at least for me and my family)

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Capronium Chloride and Trichoxidil are suggested as better alternatives to Minoxidil for hair growth without heart side effects. The Japanese Dermatological Association recommends topical Minoxidil over Capronium Chloride.

community Diagnosed with female pattern hair loss as a male with recent aggressive loss. Preemptively mourning the only part of myself I’ve ever come close to loving. Lost all motivation to do anything with my life.

in Progress Pictures 271 upvotes 2 years ago

The conclusion of the conversation is that the user should consider using treatments such as finasteride, minoxidil, and RU58841 to potentially reverse their hair loss. Other suggestions include using hair loss concealers and maintaining a healthy diet.

community Spironolactine Update: 2 months (34, Female)

in Female 24 upvotes 8 years ago

A female user's experience using Spironolactone to treat Female Pattern Hair Loss (FPHL) and Androgenic Alopecia, as well as discussing the effectiveness of the drug at different dosages.

community For the ladies: Spironolactone for FPHL

in Female 12 upvotes 9 years ago

A 34 year old female with androgenic alopecia who has tried treatments such as Spironolactone, Desogen, Minoxidil and Finasteride in order to address her hair loss. It also details the experiences of other women taking Spironolactone for Female Pattern Hair Loss (FPHL).

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