Pathogenetically Significant Risk Factors for Development of Androgenetic Alopecia

June 2023 in “ Zenodo (CERN European Organization for Nuclear Research) ”

Mavlyanova Z.N. Azimova F.V.

androgenetic alopecia microinflammation hair follicles Langerhans cells keratinocytes T lymphocytes T cell proliferation macrophages natural killer cells hair loss inflammation immune cells

TLDR Inflammation in hair follicles is a key risk factor for developing common baldness.

The document discusses the pathogenesis of androgenetic alopecia, focusing on the role of "microinflammation" in hair follicles. This multi-stage inflammatory response involves Langerhans cells and keratinocytes presenting antigens to infiltrating T lymphocytes, leading to T cell proliferation. These antigens are then selectively destroyed by infiltrating macrophages or natural killer cells. This process is suggested to be a significant risk factor in the development of androgenetic alopecia.

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