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    Glossary Hypertrophic Scars

    raised, thickened skin areas from excessive collagen after injury

    Hypertrophic scars are raised, thickened areas of skin that form at the site of an injury or incision. Unlike keloid scars, which can grow beyond the boundaries of the original wound, hypertrophic scars remain confined to the wound area but can be red, itchy, and sometimes painful. They result from an overproduction of collagen during the healing process and can improve over time, though treatments like silicone sheets, corticosteroid injections, or laser therapy may be used to reduce their appearance.

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    1. Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids International journal of molecular sciences · 2018 · 305 citations
    2. A nude mouse model of hypertrophic scar shows morphologic and histologic characteristics of human hypertrophic scar Wound repair and regeneration · 2012 · 47 citations
    3. Combination of lyophilized adipose-derived stem cell concentrated conditioned medium and polysaccharide hydrogel in the inhibition of hypertrophic scarring Stem Cell Research & Therapy · 2021 · 45 citations
    4. A novel immune competent murine hypertrophic scar contracture model: A tool to elucidate disease mechanism and develop new therapies Wound Repair and Regeneration · 2014 · 35 citations
    5. Effect of P144® (Anti-TGF-β) in an “In Vivo” Human Hypertrophic Scar Model in Nude Mice PloS one · 2015 · 32 citations
    6. Fibroblasts and endothelial cells interplay drives hypertrophic scar formation: Insights from in vitro and in vivo models Bioengineering & Translational Medicine · 2023 · 21 citations
    7. Topical Calcipotriol for Preventive Treatment of Hypertrophic Scars Archives of Dermatology · 2009 · 18 citations
    8. Mesenchymal Stem Cells From Mouse Hair Follicles Reduce Hypertrophic Scarring in a Murine Wound Healing Model Stem cell reviews and reports · 2022 · 13 citations
    9. Effects of ginsenoside Rb1 on hypertrophic scar remodeling in rabbit model European journal of pharmacology · 2015 · 10 citations
    10. Morphologic and Histologic Comparison of Hypertrophic Scar in Nude Mice, T-Cell Receptor, and Recombination Activating Gene Knockout Mice 2015 · 9 citations
    11. Transcription factor c‐Maf drives macrophages to promote hypertrophic scar formation Journal of Cosmetic Dermatology · 2023 · 5 citations
    12. Hairless Descendants of Mexican Hairless Dogs: An Experimental Model for Studying Hypertrophic Scars Journal of Cutaneous Medicine and Surgery · 2011 · 5 citations
    13. Gut microbiota-derived metabolites in keloid and hypertrophic scarring Frontiers in Microbiology · 2025 · 3 citations
    14. Hypertrophic Scar Formation on Application of Terpenoid Fraction of Tuberous Root of<i>Mirabilis jalapa</i>L. on Excision Wound Model in Wistar Albino Rats International Scholarly Research Notices · 2014 · 2 citations
    15. The expression of melatonin receptor in human hypertrophic scar Chinese journal of plastic surgery · 2010 · 1 citations
    16. Dihydromyricetin attenuates fibrosis-associated features of hypertrophic scar with accompanying changes in PI3K/AKT/mTOR-related signaling Frontiers in Pharmacology · 2026
    17. Self-Organizing 3D Dermal Papilla Cell Spheroids Yield Therapeutic Extracellular Vesicles that Target Hypertrophic Scar Regression via the miR-26a-5p/CCNE2 Axis Burns & Trauma · 2025
    18. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis Open Medicine · 2025
    19. The effect of inflammatory cytokines on the risk of hypertrophic scar: A Mendelian Randomization Study Research Square (Research Square) · 2024
    20. Morphological and distribution characteristics of sweat glands in hypertrophic scar and their possible effects on sweat gland regeneration 中华医学杂志:英文版 · 2005
    21. Dermatoscopic Patterns in Keloid, Hypertrophic, and Atrophic Scars: Cross-Sectional Analysis and Clinical Correlation Dermatology Practical & Conceptual · 2025
    22. Botulinum Toxin Type A for Preventing Facial Trauma and Hypertrophic Scars: A Meta‐Analysis and Trial Sequential Analysis Journal of Cosmetic Dermatology · 2025
    23. Pooled, Frozen, Gamma‐Irradiated Amniotic Fluid Enhances Histomorphological Remodelling in Hypertrophic Scars International Wound Journal · 2025
    24. Remolding Microenvironmental Homeostasis for Enhancing Regenerative Hypertrophic Scar Treatment Based on Functionalized Microneedles Interdisciplinary materials · 2025
    25. Addressing Keloid and Hypertrophic Scars from Hair Transplant Journal of Asia Pacific Aesthetic Sciences · 2022
    26. The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring Pharmaceutics · 2023 · 1 citations
    27. Pharmacotherapy for Keloids and Hypertrophic Scars International journal of molecular sciences · 2024
    28. Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars British journal of pharmacology · 2016 · 36 citations
    29. Regeneration of Dermis: Scarring and Cells Involved Cells · 2019 · 176 citations
    30. Toward understanding scarless skin wound healing and pathological scarring F1000Research · 2019 · 113 citations