Morphologic and Histologic Comparison of Hypertrophic Scar in Nude Mice, T-Cell Receptor, and Recombination Activating Gene Knockout Mice

    November 2015 in “ Plastic and reconstructive surgery/PSEF CD journals ”
    Moein Momtazi, Jie Ding, Peter Kwan, Colin C. Anderson, Dariush Honardoust, Serge Goekjian, Edward E. Tredget
    Studysummary This study found that human skin grafted onto certain immunodeficient mice resulted in proliferative scars with characteristics similar to human hypertrophic scars, suggesting these models may better represent the condition's natural history.
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    The study compared hypertrophic scars in different genetically modified mice strains (TCRαβ-/-γδ-/-, RAG-1-/-, and RAG-2-/-γc-/-) by grafting them with human skin and analyzing the resulting scars over time. The results showed that these mice developed firm, elevated scars with histologic and immunohistochemical similarities to human hypertrophic scars, unlike the autografted controls which did not show pathologic scarring. The knockout mice also demonstrated scar remodeling capabilities, suggesting that these models may better represent the natural history of human hypertrophic scars.
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