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GlossaryHair Shaft Elongation

process of hair growing longer from the scalp

Hair Shaft Elongation refers to the process by which the visible part of the hair, known as the hair shaft, grows longer. This occurs as cells in the hair follicle divide and push the older cells upward, causing the hair to extend out from the scalp. This process is influenced by various factors including genetics, nutrition, and overall health.

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Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro

research Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro

60 citations, May 2014 in “British Journal of Dermatology”

Caffeine affects hair growth and health differently in men and women.

research Enhancement of In Vitro Hair Shaft Elongation in Follicles Stored in Buffers That Prevent Follicle Cell Apoptosis

10 citations, January 2004 in “Dermatologic Surgery”

Storing hair follicles in special buffers with added protective substances can increase hair growth and reduce cell death.

research Vitamins and Their Derivatives Synergistically Promote Hair Shaft Elongation via PlGF/VEGFR-1 Signalling Activation

1 citations, September 2022 in “Journal of dermatological science”

Certain vitamins and their derivatives can help hair grow longer by activating specific growth signals.

research Dermal White Adipose Tissue Enhances Proliferation, Pigmentation, and Hair Shaft Elongation in Human Hair Follicles Ex Vivo

May 2018 in “Journal of Investigative Dermatology”

Fat under the skin can help hair grow longer, darker, and increase cell growth.

research Enhancement of In Vitro Hair Shaft Elongation in Follicles Stored in Buffers That Prevent Follicle Cell Apoptosis

January 2004 in “Dermatologic Surgery”

Storing hair follicles in a special buffer with certain inhibitors can increase hair growth and improve transplant results.

Tectoridin Stimulates the Activity of Human Dermal Papilla Cells and Promotes Hair Shaft Elongation in Mouse Vibrissae Hair Follicle Culture

research Tectoridin Stimulates the Activity of Human Dermal Papilla Cells and Promotes Hair Shaft Elongation in Mouse Vibrissae Hair Follicle Culture

7 citations, January 2022 in “Molecules”

Tectoridin helps human hair cells grow and makes mouse hair longer, suggesting it could treat hair loss.

Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor Beta 2 Expression

research Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor Beta 2 Expression

64 citations, March 2005 in “Journal of Investigative Dermatology”

Brain-Derived Neurotrophic Factor (BDNF) slows down hair growth and promotes hair follicle regression.

research L-Ascorbic Acid 2-Phosphate Promotes Elongation of Hair Shafts via the Secretion of Insulin-Like Growth Factor-1 from Dermal Papilla Cells Through Phosphatidylinositol 3-Kinase

34 citations, June 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.

research 6-Gingerol Inhibits Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice

17 citations, February 2013 in “PLOS ONE”

6-Gingerol, found in ginger, may slow down hair growth and could be used for hair removal.

research Skin And Hair On-A-Chip: In Vitro Skin Models Versus Ex Vivo Tissue Maintenance With Dynamic Perfusion

208 citations, January 2013 in “Lab on a Chip”

The Multi-Organ-Chip improves the growth and quality of skin and hair in the lab, potentially replacing animal testing.

research A Hot New Twist to Hair Biology: The Role of TRPV1 in Human Hair Growth Control

174 citations, April 2005 in “The American journal of pathology (Print)”

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

research Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

128 citations, March 2006 in “American Journal of Pathology”

Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

research Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells

81 citations, December 2009 in “Journal of Dermatological Science”

Fat tissue stem cells may help increase hair growth.

research Thyrotropin Releasing Hormone: A New Player in Human Hair Growth Control

72 citations, October 2009 in “The FASEB journal”

TRH stimulates human hair growth and extends the hair growth phase.

research Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions

61 citations, July 2011 in “PLOS ONE”

Spermidine may help reduce hair loss and deserves further testing as a treatment.

research Growth of Secondary Hair Follicles of the Cashmere Goat In Vitro and Their Response to Prolactin and Melatonin

56 citations, August 1994 in “PubMed”

Prolactin and melatonin can stimulate hair growth in Cashmere goat hair follicles, but melatonin may reduce follicle viability over time.

research Profiling the Response of Human Hair Follicles to Ultraviolet Radiation

53 citations, January 2009 in “Journal of Investigative Dermatology”

UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.

research Estrogens And The Hair Follicle

50 citations, May 2004 in “Journal der Deutschen Dermatologischen Gesellschaft”

Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.