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    Glossary Granulation Tissue Formation

    formation of new connective tissue and blood vessels during wound healing

    Granulation tissue formation is a crucial phase in the wound healing process where new connective tissue and tiny blood vessels form on the surface of a wound. This tissue is typically pink or red and granular in appearance, indicating that the body is actively repairing the damaged area by providing a scaffold for new skin cells to grow.

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    1. Obstruction of the formation of granulation tissue leads to delayed wound healing after scald burn injury in mice Burns & Trauma · 2021 · 28 citations
    2. Comparison of the Therapeutic Effect of Allogeneic and Xenogeneic Small Extracellular Vesicles in Soft Tissue Repair International Journal of Nanomedicine · 2020 · 18 citations
    3. Wound healing with topical BRAF inhibitor therapy in a diabetic model suggests tissue regenerative effects PLOS ONE · 2021 · 3 citations
    4. Formulation and Application of a Human Insulin-Like Growth Factor 1-Loaded Transfersomal System to Enhance Skin Wound Healing in Diabetic Rat Models International Journal of Nanomedicine · 2026
    5. Gallic Acid Nanocrystal Hydrogel: A Novel Strategy for Promoting Wound Healing and Inhibiting Scar Formation International Journal of Nanomedicine · 2025 · 13 citations
    6. Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing International journal of molecular sciences · 2020 · 263 citations
    7. Hyaluronidase Modulates Inflammatory Response and Accelerates the Cutaneous Wound Healing PLoS ONE · 2014 · 98 citations
    8. Ligand-Dependent Actions of the Vitamin D Receptor Are Required for Activation of TGF-β Signaling during the Inflammatory Response to Cutaneous Injury Endocrinology · 2012 · 56 citations
    9. Macrophage ferroportin is essential for stromal cell proliferation in wound healing Haematologica · 2018 · 45 citations
    10. Electrospun fibrous sponge via short fiber for mimicking 3D ECM Journal of Nanobiotechnology · 2021 · 34 citations
    11. The Effect of Mesenchymal Stem Cells and Chitosan Gel on Full Thickness Skin Wound Healing in Albino Rats: Histological, Immunohistochemical and Fluorescent Study PLOS ONE · 2015 · 23 citations
    12. Platelet-Rich Plasma: Principles and Applications in Plastic Surgery Seminars in Plastic Surgery · 2019 · 19 citations
    13. Biological Macromolecule Hydrogel Based on Recombinant Type I Collagen/Chitosan Scaffold to Accelerate Full-Thickness Healing of Skin Wounds Polymers · 2023 · 12 citations
    14. Poloxam Thermosensitive Hydrogels Loaded with hFGF2-Linked Camelina Lipid Droplets Accelerate Skin Regeneration in Deep Second-Degree Burns International Journal of Molecular Sciences · 2022 · 8 citations
    15. Different effects of a perioperative single dose of dexamethasone on wound healing in mice with or without sepsis Frontiers in Surgery · 2023 · 7 citations
    16. Exosome laden sprayable thermo-sensitive polysaccharide-based hydrogel for enhanced burn wound healing International Journal of Biological Macromolecules · 2024 · 6 citations
    17. The efficacy of adipose-derived stem cells in burn injuries: a systematic review Cellular & Molecular Biology Letters · 2024 · 1 citations
    18. Comparative effects of Pistacia atlantica leaf and phenytoin ointment on rat skin wound healing: histopathological changes and bioactive compounds Inflammopharmacology · 2026
    19. Eco-engineered recombinant collagen III-PEG hydrogels with curcumin synergy for accelerated skin regeneration: A green crosslinking strategy in wound therapeutics International Journal of Biological Macromolecules · 2025
    20. Hydrogel film sheets-based medicinal plants for diabetic wound dressing application: A review AIP conference proceedings · 2024
    21. Effect of Aqueous Extract Iraqi Aloe vera on Treatment of Skin Wounds in Rabbits Academic International Journal of Veterinary Medicine · 2025
    22. A comparative study of the effects of 4-META/MMA-TBB resin and cyanoacrylate on wound healing of skin defects Journal of Biomedical Materials Research Part B: Applied Biomaterials · 2015
    23. Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis EMBO journal · 2001 · 163 citations
    24. Differential cutaneous wound healing in thermally injured MRL/MPJ mice Wound Repair and Regeneration · 2007 · 26 citations
    25. The Model of an Ischemic Non-Healing Wound: Regeneration after Transplantation of a Living Skin Equivalent Sovremennye tehnologii v medicine · 2023
    26. Design of an artificial skin. IV. Use of island graft to isolate organ regeneration from scar synthesis and other processes leading to skin wound closure Journal of Biomedical Materials Research · 1998 · 13 citations
    27. Skin cell-derived extracellular vesicles: a promising therapeutic strategy for cutaneous injury Burns and trauma · 2022 · 8 citations
    28. Skin-inspired phototherapeutic cryogel ameliorates infected wound healing by orchestrating mechanotransduction and immunomodulation Bioactive Materials · 2025
    29. Antioxidant and anti-inflammatory properties of pine pollen extract promote wound healing Materials Express · 2023
    30. Activation and regulation of the granulation tissue derived cells with stemness-related properties Stem Cell Research & Therapy · 2015 · 14 citations