Granulation Tissue Developed After Minor Trauma in a Psoriatic Patient on Long-Term Etretinate Therapy

In 1990, a case study was reported involving a 44-year-old male psoriatic patient who developed granulation tissue after a minor injury while on long-term etretinate therapy (30 mg/day for 3 years). The wound did not heal with topical disinfectants and oral antibiotics and showed erythema and secretion of clear exudate. Histological analysis indicated proliferating microvessels and a dense infiltration of plasma cells in the swollen connective tissue, suggesting that the granulation tissue was a result of the retinoid treatment. The case was significant due to the rash's development post-injury, its location on the lower leg, and the presence of eosinophil infiltration. The study concluded with a warning for long-term etretinate users about the risk of delayed wound healing and granulation tissue formation.