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Glossary Secondary Intention Healing

wound heals naturally from the bottom up without stitches

Secondary Intention Healing refers to the process by which a wound heals naturally without surgical closure. Instead of stitching the wound edges together, the wound is left open and heals from the bottom up, through the formation of granulation tissue, contraction, and epithelialization. This method is often used for large, infected, or non-approximable wounds and typically results in a larger scar compared to primary intention healing.

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Research

5 / 1000+ results

research Surgical excision of acne keloidalis nuchae with secondary intention healing

24 citations , October 2007 in “Clinical and experimental dermatology”

This case report describes two men with acne keloidalis nuchae who experienced successful outcomes with excision followed by secondary intention healing, resulting in good cosmetic results and minimal recurrence.

research Never too old to regenerate? Wound induced hair follicle neogenesis after secondary intention healing in a geriatric patient

7 citations , January 2018 in “Journal of Tissue Viability”

This case report describes an 80-year-old patient whose scalp wound healed by secondary intention, with unexpected hair regrowth observed at 180 days, suggesting hair neogenesis is possible even in older adults.

research γδ T cells mediate a requisite portion of a wound healing response triggered by cutaneous poxvirus infection

1 citations , September 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that skin-resident and recruited γδ T cells play a crucial role in an early wound healing response following cutaneous vaccinia virus infection, rather than in controlling virus replication.

research Beyond Comfortable: A Removable Antibacterial Electroconductive Cellulose Nonwoven Dressing for Accelerated Wound Healing

2 citations , December 2025 in “Nano Letters”

This study developed a tannin-modified cellulose-polypyrrole dressing that accelerates wound healing by enhancing granulation tissue, optimizing collagen, and stimulating angiogenesis, while providing antibacterial protection against S. aureus and E. coli.

research Hyaluronic Acid Hydrogel Incorporating Dexpanthenol-Engineered Extracellular Vesicles for Accelerated Wound Closure and Mitigated Secondary Infection Risk

August 2026 in “Pharmaceutics”

In this study, researchers developed a dexpanthenol-infused nanotechnological platform within hyaluronic acid hydrogels that promoted wound healing in mice by providing a protective barrier and significantly enhancing skin regeneration, including increased fibroblast activity and tissue remodeling.

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Community Join

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community Are Derma Rollers Actually Harmful in the Long Run?

in Microneedling 40 upvotes 1 year ago

Derma rollers may cause scarring alopecia, leading some to prefer dermastamps or dermapens for microneedling. Combining minoxidil with microneedling is effective, but proper technique and healing time are essential to prevent damage.

community Oral 1mg Finesteride 2mg Minoxidil

485 upvotes 4 months ago

The user experienced significant hair regrowth using 1mg finasteride and 2mg minoxidil daily, along with Nizoral shampoo and rosemary oil. They are curious about further improving hair density and whether increasing the minoxidil dose would help.

community Realistically, how much PP405 will cost?

33 upvotes 1 year ago

PP405 is in phase 2 trials for hair loss, with discussions on its cost and effectiveness compared to minoxidil and finasteride. Users are skeptical about its efficacy and timeline, with hopes for market release by 2027.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Before and after: 1 year of Min, 8 months of Fin

355 upvotes 5 months ago

Improved hair density and texture after using 1mg oral finasteride and 5mg oral minoxidil for a year. The user is satisfied with the results, noting no significant side effects except reduced seminal volume.

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Learn

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learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Hair Transplant

What are the risks and side effects of FUE hair transplants? Providers describe most FUE side effects, such as swelling, redness, numbness and shock loss, as temporary, but FUE is surgery and the same sources report pain, infection, folliculitis and small permanent donor-site scars. Longer-lasting problems, including visible donor-area thinning or poor graft growth, are possible and are not covered by this provider survey.

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