Locally Delivered Umbilical Cord Mesenchymal Stromal Cells Reduce Chronic Inflammation in Long-Term Nonhealing Wounds: A Randomized Study

    February 2020 in “ Stem Cells International ”
    Yulia Suzdaltseva, Sergey Zhidkih, Sergey L. Kiselev, Victor Stupin
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    Studysummary This study reported that a single local subcutaneous infusion of mesenchymal stromal cells from the human umbilical cord promoted wound healing, improved blood circulation, and reduced wound size in patients with chronic wounds without significant adverse effects over one year. Our plain-language summary of this paper — not a Tressless recommendation.
    In a randomized clinical study involving 108 patients with chronic nonhealing wounds, the efficacy and safety of umbilical cord mesenchymal stromal cells (UCMSCs) were evaluated. The patients were divided into two groups, with 59 receiving UCMSC therapy and 49 receiving a placebo. The UCMSC group was treated with a single injection of 2 × 10^7 cells, while the placebo group received a saline solution. The study found that UCMSC treatment significantly improved wound healing, with increased granulation tissue formation, enhanced microcirculation, and reduced wound size compared to the placebo group. Four weeks after treatment, 22% of the UCMSC group showed complete wound closure or significant improvement, versus 8.2% in the placebo group. No adverse effects were reported, leading to the conclusion that UCMSC therapy is a safe and effective method for promoting the healing of chronic wounds.
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