Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study suggests that CD8+ cytotoxic T lymphocytes play a crucial role in the development of alopecia areata, based on observations in rodent models that mimic human autoimmune disease.

This study found that treating male rats with human hair follicle stem cells improved memory function impaired by streptozotocin and increased both neurotrophic and inflammatory markers, suggesting potential neuroprotective effects in this model.

This article reviews organotypic skin culture systems and their applications in dermatological research, highlighting their ability to model human epidermal conditions in vitro, but it reports no new clinical results.

Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.

This review describes bioengineering strategies to mimic the natural cell microenvironment in vitro, emphasizing the novel approach of using cell-synthesized extracellular matrix as a scaffold for engineering functional 3D tissues, while highlighting the limitations of exogenous scaffolds in tissue engineering.

In vitro skin models are improving but still need more innovation to fully replicate human skin.

This review summarizes the therapeutic potential and development of engineered extracellular vesicles for tissue repair and regenerative medicine, reporting no new clinical findings.

This study found that injecting mouse hair follicle-derived mesenchymal stem cells (moMSCORS) into C57BL/6 mice reduced the incidence and severity of type 1 diabetes by modulating immune responses, suggesting potential for therapeutic use due to their immunosuppressive effects.

In this study, the misshaped and hairy ear phenotype in mutant mice was linked to mis-expression of certain Hoxc genes due to a chromosomal inversion.

This review discusses the role of extracellular vesicles as therapeutic agents for wound healing and highlights the need for further research into their clinical applications.

This publication provides a standardized nomenclature for classifying microscopic lesions in laboratory rat and mouse skin, aiming to harmonize international toxicological research.

This study found that mice with a homozygous knockout of the Ten1 gene, developed through CRISPR-Cas9-mediated exon 3 deletion, exhibited telomere shortening and symptoms consistent with accelerated aging, such as reduced lifespan, skin changes, aplastic anemia, and cerebellar hypoplasia.

In this study, intranasal delivery of hair follicle-derived stem cells improved neurological function and reduced brain damage in a rat model of ischemic stroke.

This study found that external and internal luteolin treatments reduced hair graying in model mice by mitigating age-related dysfunction in hair stem cell signaling, suggesting potential practical applications for anti-graying treatment in humans.

This review reports that cerium oxide nanoparticles may accelerate wound healing in animal models, but further standardized and comparative studies are needed to confirm their potential for clinical applications.

This review highlighted that in an in vitro setting, 3D spheroid cultures of fish cells offer a promising alternative to traditional monolayer cultures, potentially advancing research in eco-toxicology, immunology, drug screening, and more by better mimicking in vivo conditions.

This study found that injecting interferon gamma into C3H/HeJ mice did not alter the frequency or onset of alopecia areata, suggesting the protein alone does not trigger the disease.

This review discusses the role of telomere length dynamics in hair follicle biology and reports no new clinical findings, emphasizing the need for further research in humans.

This study found that hairless mice with homozygous mutations developed significantly more aggressive basal cell carcinomas and a heightened inflammatory response to UVB exposure compared to their haired littermates.

In this study, researchers found that while blocking either glycolysis or glutaminolysis in cancer cells did not prevent tumor growth due to metabolic flexibility, simultaneous inhibition of both pathways hindered carcinoma development, indicating multiple interventions may be necessary for effective metabolic manipulation in cancer treatment.

This review discusses the potential of exosomes and the secretome in stem cell-based regenerative therapies but reports no new experimental findings.

This study found that in mice lacking EGFR, elevated Wnt signaling disrupts hair follicle development by affecting cell proliferation and differentiation, revealing a critical role for EGFR in regulating these processes.

This review discusses the interactions between melanocyte stem cells and their niche in hair regeneration and repair, but reports no new results; recent studies on molecular pathways are highlighted.

This article discusses the potential of RNA-based biopesticides for sustainable agriculture and reports no new experimental results; it highlights the need for improved delivery systems and regulatory development to enhance deployment.

This study found that doxorubicin induces hair follicle apoptosis through TRAIL receptor signaling, providing insights for managing chemotherapy-induced hair loss.

This study found that mutations in the TULP3 gene are associated with progressive degeneration of the liver, kidney, and heart in adults, highlighting the importance of early detection and management.

The study emphasizes that telomere shortening is identified as the sole cause of aging among the twelve hallmarks and suggests that increasing telomere and rDNA array length in adult stem cells might effectively reverse aging and extend lifespan.

This study identified a specific genetic variant in the CCHCR1 gene that may contribute to alopecia areata through impaired keratinization, suggesting an alternative mechanism beyond autoimmune causes.

Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.

This review examines cell-based therapies for limbal stem cell deficiency, highlighting epidermal and hair follicle-derived stem cells as promising candidates for future clinical trials, but reports no new clinical findings.