Loss of Ten1 in Mice Induces Telomere Shortening and Models Human Dyskeratosis Congenita

April 2025 in “ Science Advances ”

Adrián Sanz‐Moreno, Lore Becker, Kan Xie, Patricia da Silva‐Buttkus, Nathalia Romanelli Vicente Dragano, Juan Antonio Aguilar‐Pimentel, Oana V. Amarie, Julia Calzada‐Wack, Markus Kraiger, Stefanie Leuchtenberger, Claudia Seisenberger, Susan Marschall, Birgit Rathkolb, Enzo Scifo, Ting Liu, Anoja Thanabalasingam, Raúl Sánchez-Vazquez, Paula Felippe Martinez, Marı́a A. Blasco, Sharon A. Savage, Helmut Fuchs, Dan Ehninger, Valérie Gailus‐Durner, Martin Hrabě de Angelis

Ten1 telomere shortening dyskeratosis congenita CRISPR-Cas9 alopecia skin hyperpigmentation telomere biology p53/p21 signaling pathway stem cell depletion hair loss skin discoloration gene editing

Studysummary This study found that mice with a homozygous knockout of the Ten1 gene, developed through CRISPR-Cas9-mediated exon 3 deletion, exhibited telomere shortening and symptoms consistent with accelerated aging, such as reduced lifespan, skin changes, aplastic anemia, and cerebellar hypoplasia.

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Association Between Genetically Predicted Leukocyte Telomere Length and Non-Scarring Alopecia: A Two-Sample Mendelian Randomization Study

research Association Between Genetically Predicted Leukocyte Telomere Length and Non-Scarring Alopecia: A Two-Sample Mendelian Randomization Study

4 citations , January 2023 in “Frontiers in Immunology”

In this Mendelian randomization study, shortened leukocyte telomere length was associated with an increased risk of androgenetic alopecia, but no causal relationship was found with alopecia areata.

research Telomere Dynamics and Telomerase in the Biology of Hair Follicles and Their Stem Cells as a Model for Aging Research

12 citations , January 2021 in “Journal of Investigative Dermatology”

This review discusses the role of telomere length dynamics in hair follicle biology and reports no new clinical findings, emphasizing the need for further research in humans.