Loss of Ten1 in Mice Induces Telomere Shortening and Models Human Dyskeratosis Congenita

    April 2025 in “ Science Advances ”
    Adrián Sanz‐Moreno, Lore Becker, Kan Xie … Martin Hrabě de Angelis
    Studysummary This study found that mice with a homozygous knockout of the Ten1 gene, developed through CRISPR-Cas9-mediated exon 3 deletion, exhibited telomere shortening and symptoms consistent with accelerated aging, such as reduced lifespan, skin changes, aplastic anemia, and cerebellar hypoplasia.
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    Research cited in this study 2

    1. Association Between Genetically Predicted Leukocyte Telomere Length and Non-Scarring Alopecia: A Two-Sample Mendelian Randomization Study Frontiers in Immunology · 2023
    2. Telomere Dynamics and Telomerase in the Biology of Hair Follicles and Their Stem Cells as a Model for Aging Research Journal of Investigative Dermatology · 2021