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Glossary p53 Signaling Pathway

regulates cell cycle and prevents cancer by responding to DNA damage

The p53 Signaling Pathway, also known as the TP53 Pathway, is a crucial cellular mechanism that helps regulate the cell cycle and prevent cancer. The p53 protein, often called the "guardian of the genome," activates in response to DNA damage or stress, leading to cell cycle arrest, DNA repair, or apoptosis (programmed cell death) to maintain genetic stability.

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research Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita

3 citations , April 2025 in “Science Advances”

This study found that mice with a homozygous knockout of the Ten1 gene, developed through CRISPR-Cas9-mediated exon 3 deletion, exhibited telomere shortening and symptoms consistent with accelerated aging, such as reduced lifespan, skin changes, aplastic anemia, and cerebellar hypoplasia.

research Epimorphic regeneration in mice is p53-independent

20 citations , September 2010 in “Cell Cycle”

This study reports that in MRL mice, loss of p53 does not impair ear regeneration, suggesting p21's potential role in this process may involve the Tgfb/Smad pathway.

research Ethanol extract of asiasari radix preferentially induces apoptosis in G361 human melanoma cells by differential regulation of p53

2 citations , August 2019 in “BMC Complementary and Alternative Medicine”

This study found that ethanolic asiasari radix extract may induce apoptosis in G361 melanoma cells through ROS-dependent regulation of p53, suggesting potential as a medicinal option for melanoma.

research PAK4 signaling in health and disease: defining the PAK4–CREB axis

81 citations , February 2019 in “Experimental & Molecular Medicine”

This review examines PAK4 signaling pathways in prostate cancer, Parkinson's disease, and melanogenesis, focusing on the potential role of the PAK4-CREB axis, without reporting new clinical results.

Transient Mitochondrial DNA Double Strand Breaks in Mice Cause Accelerated Aging Phenotypes in a ROS-Dependent but p53/p21-Independent Manner

research Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

42 citations , December 2016 in “Cell Death & Differentiation”

This study found that transient mtDNA double strand breaks in mice accelerated aging in certain tissues through increased reactive oxygen species, independent of p21/p53 pathway mediation.

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community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

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