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    Glossary p53 Signaling Pathway

    regulates cell cycle and prevents cancer by responding to DNA damage

    The p53 Signaling Pathway, also known as the TP53 Pathway, is a crucial cellular mechanism that helps regulate the cell cycle and prevent cancer. The p53 protein, often called the "guardian of the genome," activates in response to DNA damage or stress, leading to cell cycle arrest, DNA repair, or apoptosis (programmed cell death) to maintain genetic stability.

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    Research 30 of 1000+

    1. Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita Science Advances · 2025 · 3 citations
    2. Epimorphic regeneration in mice is p53-independent Cell Cycle · 2010 · 20 citations
    3. Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues The Journal of Physiology · 2015 · 8 citations
    4. Ethanol extract of asiasari radix preferentially induces apoptosis in G361 human melanoma cells by differential regulation of p53 BMC Complementary and Alternative Medicine · 2019 · 2 citations
    5. PAK4 signaling in health and disease: defining the PAK4–CREB axis Experimental & Molecular Medicine · 2019 · 81 citations
    6. Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner Cell Death & Differentiation · 2016 · 42 citations
    7. 4-<i>O</i>-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling Biomolecules & Therapeutics · 2017 · 5 citations
    8. CXXC5: A novel regulator and coordinator of TGF-β, BMP and Wnt signaling Journal of Cellular and Molecular Medicine · 2018 · 28 citations
    9. Molecular Regulation of Melanocyte Senescence Pigment Cell Research · 2002 · 85 citations
    10. Protective Effects of Korean Red Ginseng Against Oxidative Stress-Induced Damage in Human Hair Annals of Dermatology · 2024
    11. Effect of Liquid Blood Concentrates on Cell Proliferation and Cell Cycle- and Apoptosis-Related Gene Expressions in Nonmelanoma Skin Cancer Cells: A Comparative In Vitro Study International Journal of Molecular Sciences · 2024
    12. Cell Cycle Regulation and Regeneration Current Topics in Microbiology and Immunology · 2012 · 27 citations
    13. Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/Fas L-Mediated Apoptotic Signaling PloS one · 2014 · 29 citations
    14. SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cell Migration to the Epidermis through p53/Stem Cell Factor/C-KIT Signaling Journal of Investigative Dermatology · 2024 · 4 citations
    15. p63 Regulates Human Keratinocyte Proliferation via MYC-regulated Gene Network and Differentiation Commitment through Cell Adhesion-related Gene Network Journal of Biological Chemistry · 2011 · 82 citations
    16. Platycladus orientalis Leaf Extract Promotes Hair Growth via Non-Receptor Tyrosine Kinase ACK1 Activation Current Issues in Molecular Biology · 2024
    17. Protective Effect of Iris germanica L. Rhizome-Derived Exosome against Oxidative-Stress-Induced Cellular Senescence in Human Epidermal Keratinocytes Applied sciences · 2023
    18. Role of the Wnt signaling pathway in keratoacanthoma Cancer reports · 2019 · 2 citations
    19. Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways InTech eBooks · 2017 · 1 citations
    20. Regulation of pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway (Review) Molecular Medicine Reports · 2021 · 18 citations
    21. Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway Oncotarget · 2017 · 11 citations
    22. Signaling pathways in hair aging Frontiers in cell and developmental biology · 2023
    23. PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis Stem Cell Research & Therapy · 2019 · 26 citations
    24. Genome Wide Differential Expression Profiles in Nevus Sebaceous Uncovered Low Expression of CDKN2AIP and Construction of a ceRNA Network Clinical Cosmetic and Investigational Dermatology · 2022
    25. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020 · 51 citations
    26. Regulatory effect of β-catenin on proliferation of hair follicle stem cells involves PI3K/Akt pathway Journal of Applied Biomedicine · 2013 · 11 citations
    27. Removing all obstacles: A critical role for p53 in promoting tissue renewal Cell Cycle · 2010 · 30 citations
    28. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014 · 223 citations
    29. Peripheral blood gene expression in alopecia areata reveals molecular pathways distinguishing heritability, disease and severity Genes and Immunity · 2010 · 20 citations
    30. Replicative stress, stem cells and aging Mechanisms of Ageing and Development · 2008 · 70 citations