Anti-Graying Effects of External and Internal Treatments with Luteolin on Hair in Model Mice

The study explored the anti-graying effects of luteolin on hair in model mice, demonstrating that both external and internal treatments with luteolin significantly reduced hair graying. Luteolin was found to suppress the increase of p16ink4a-positive cells in keratinocyte stem cells and maintain endothelin signaling in melanocyte stem cells, which are crucial for hair pigmentation. External treatment was more effective than internal treatment, while other flavonoids like hesperetin and diosmetin showed no significant effects. The study suggests luteolin's potential as an anti-graying treatment for humans, given the similarities in hair graying processes between mice and humans. Further research is needed to confirm its safety and efficacy in humans.