14 citations
,
May 2012 in “Endocrine Research” This study found diverse responses to the androgen dihydrotestosterone in rodent tissues, with most androgen-regulated processes being specific to particular tissues.
14 citations
,
September 2010 in “Annals of Plastic Surgery” This article reviews recent advancements in understanding hair follicle biology, with a focus on the potential for gene therapy in treating alopecia, but it reports no new research findings.
14 citations
,
July 1994 in “Journal of Dermatological Science” In this study, transgenic mice expressing a mutant K6 gene developed progressive scarring alopecia and keratosis, suggesting they may model a new keratin disorder.
14 citations
,
April 2021 in “Biology” This study found that ethanol extract of Tubtim Chumphae rice bran downregulates SRD5A gene expression, similarly to finasteride, suggesting potential use as an anti-hair loss product.
14 citations
,
May 2020 in “Archiv für Tierzucht” This study found that genes such as FGF5, FGFR1, and RRAS may impact the growth cycle of secondary hair follicles in Inner Mongolian Cashmere goats.
14 citations
,
September 2017 in “General and comparative endocrinology” In this study, researchers observed that in barn owls, the relationship between black feather spot size and testosterone levels varied by age and sex, suggesting involvement of genes regulating both traits rather than direct influence of testosterone on feather coloration.
14 citations
,
March 2016 in “PloS one” This study found that spaceflight alters gene expression in human hair follicles, with variations among astronauts, and suggests that spaceflight may inhibit cell proliferation in hair follicles.
14 citations
,
February 2008 in “Stem Cells and Development” This study identified several genes highly expressed in germ-line stem cells that are also common in hematopoietic stem cells, potentially aiding the exploration of fundamental stem cell commonalities.
14 citations
,
January 2008 in “Gene therapy” Gene therapy shows promise for enhancing physical traits but faces ethical, safety, and regulatory challenges.
14 citations
,
October 2000 in “Genomics” This study demonstrated that dermal papilla cells are molecularly distinct from fibroblasts and identified many novel molecules, including a new member of the CTGF protein family.
13 citations
,
July 2024 in “BMC Genomics” In this study, researchers found that single SNPs have a small genetic effect on phenotypes in Inner Mongolia cashmere goats, and constructing haplotypes from associated SNPs may uncover complex variations in cashmere traits, aiding genomics and breeding efforts.
13 citations
,
October 2020 in “BMC Genomics” This study revealed specific patterns and potential functions of long non-coding RNAs during the hair follicle cycle of yaks, offering insights into their sequence conservation between yaks and cashmere goats.
13 citations
,
April 2021 in “International Journal of Molecular Sciences” This study found that the fermented black soybean product GR-SC65 reduced particulate matter-induced cell death and oxidative stress in A549 cells, suggesting potential as a therapeutic agent for lung injury prevention.
13 citations
,
August 2018 in “Journal of Molecular and Cellular Cardiology” This study demonstrated that finasteride treatment reduced cardiac dysfunction and hypertrophic remodeling in mice after myocardial infarction, suggesting potential as a therapeutic strategy for heart failure.
13 citations
,
July 2018 in “General and comparative endocrinology” This study observed that direct exposure to androgens in Western clawed frogs differentially affects thyroid receptor and deiodinase gene expression in male and female tissues, offering insight into sex-specific metabolic pathway activation.
13 citations
,
August 2017 in “Scientific reports” This study designed a 66 K SNP chip using solution hybrid selection for cashmere goats, reporting SNP call rates between 95.3% and 99.8% and demonstrating its utility in genomic analyses, suggesting potential application for other species.
13 citations
,
March 2017 in “Genomics” This study reported that pathways related to apoptosis, cell proliferation, and WNT signaling might be key drivers of hair loss in androgenetic alopecia, guiding potential targets for therapy development.
13 citations
,
January 2015 in “Steroids” This study generated a pharmacophoric model for both isoforms of steroidal 5α-reductase using 6-azasteroids, providing a structural framework for designing new inhibitors.
13 citations
,
December 2014 in “Stem Cells” This study found that quiescent bulge stem cells, when prevented from contributing to hair follicle and epidermal regeneration, did not affect hair follicle growth or wound healing in the short term.
13 citations
,
September 2007 in “International Journal of Dermatology” This study suggests no significant association between vitamin D receptor gene polymorphisms and alopecia areata.
13 citations
,
November 2005 in “Veterinary Dermatology” This study reports that a German Shepherd developed generalized calcinosis cutis following a presumed bacterial infection, representing the first known case linked to such an infection in adult dogs.
12 citations
,
August 2018 in “Journal of Dermatological Science” This study observed that adipose-derived stem cells modified with trichogenic factors have similar properties to dermal papilla cells and show enhanced hair regeneration potential compared to unmodified adipose-derived stem cells.
12 citations
,
June 2017 in “Cell Cycle” This study observed that 5% minoxidil topical foam alters gene expression and signaling pathways in the scalp, providing insights into its mechanism of action in men with androgenetic alopecia.
12 citations
,
February 2022 in “Gene” In this study, researchers found that the FOS gene may play a significant role in promoting hair follicle development in Tan sheep between birth and the Er-mao period.
12 citations
,
January 2021 in “International Journal of Biological Sciences” This study generated a gene-edited cashmere goat with improved cashmere yield and fiber length by integrating VEGF at the FGF5 site, offering insights into hair growth mechanisms.
12 citations
,
January 2018 in “Journal of Clinical Laboratory Analysis” This study found that IL-18 rs187238 and rs1946518 single nucleotide polymorphisms were associated with increased susceptibility to alopecia areata in a Turkish population.
12 citations
,
July 2015 in “Tissue Antigens” In this study, the AA genotype of C2 polymorphism was more frequently observed in Chinese patients with systemic lupus erythematosus than controls, indicating it may be a risk factor for the disease.
12 citations
,
June 2013 in “Gene” This study identified seven gene sequences related to Type III Brush Hair formation in Yangtze River Delta white goats, contributing to our understanding of hair growth and follicle cycles.
12 citations
,
January 2013 in “International Journal of Genomics” In this study, researchers used mRNA sequencing to identify and categorize over 49,000 contigs in goat skin, revealing significant gene activity related to metabolism, cell cycle, and cell division during hair growth.
12 citations
,
July 2010 in “Journal of Dispersion Science and Technology” This study found that elastic liposomes enhanced skin delivery of genistein in haired skin compared to conventional liposomes, but showed decreased effectiveness in hairless skin.