Generation of Comparative Pharmacophoric Model for Steroidal 5α-Reductase I and II Inhibitors: A 3D-QSAR Study on 6-Azasteroids

    January 2015 in “ Steroids ”
    Suresh Thareja, Tarun Rajpoot, Sant Kumar Verma
    Studysummary This study generated a pharmacophoric model for both isoforms of steroidal 5α-reductase using 6-azasteroids, providing a structural framework for designing new inhibitors.
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    Research cited in this study 6

    1. Steroidal 5α-Reductase and 17α-Hydroxylase/17,20-Lyase (CYP17) Inhibitors Useful in the Treatment of Prostatic Diseases The Journal of Steroid Biochemistry and Molecular Biology · 2013
    2. Synthesis and Biological Evaluation of Novel Unsaturated Carboxysteroids as Human 5α-Reductase Inhibitors: A Legitimate Approach European journal of medicinal chemistry · 2012
    3. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    4. An Overview on 5α-Reductase Inhibitors Steroids · 2009
    5. The 5 Alpha-Reductase System and Its Inhibitors Dermatology · 1996
    6. Structure of Human Type II 5 Alpha-Reductase Gene Endocrinology · 1992

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    1. Establishment of Type II 5α-Reductase Over-Expressing Cell Line as an Inhibitor Screening Model Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 2007