Identification of Transcripts Commonly Expressed in Both Hematopoietic and Germ-Line Stem Cells

    February 2008 in “ Stem Cells and Development ”
    Takuo Mizukami, Madoka Kuramitsu, Kazuya Takizawa, Haruka Momose, Atsuko Masumi, Seishiro Naito, Atsushi Iwama, Takehiko Ogawa, Toshiaki Noce, Isao Hamaguchi, Kazunari Yamaguchi
    TLDR Seven genes are highly expressed in both germ-line and hematopoietic stem cells.
    The study identified 11 genes highly expressed in germ-line stem cells (GSCs) through subtractive hybridization using cDNA from GSCs, testis, and embryonic stem cells. Among these, seven genes—Fth1, Cryαb, Spp1, Bcap31, Arhgap1, Ctla2α, and Serpina3g—were also highly expressed in hematopoietic stem cells (HSCs). Histological analysis confirmed the presence of Ctla2α-, Serpina3g-, and Spp1-expressing cells in the bone marrow's trabecular bone region, the HSC niche. Notably, Spp1 was also expressed in the hair follicle bulge, the hair follicle stem cell niche. This research demonstrated that identifying stemness genes through comparative analysis with GSCs was an effective method for exploring commonalities among different stem cell types.
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