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GlossaryGasdermin A3

protein crucial for hair follicle development and growth

Gasdermin A3 is a protein that plays a crucial role in the regulation of hair follicle development and hair growth. It is part of the gasdermin family, which is involved in cell differentiation and apoptosis (programmed cell death). Mutations or dysregulation of Gasdermin A3 can lead to hair disorders, such as alopecia, where hair loss occurs due to the disruption of normal hair follicle function.

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Umbilical Cord Mesenchymal Stem Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Cutaneous Wound Healing in Type 2 Diabetic Mice via Macrophage Pyroptosis Inhibition

research Umbilical Cord Mesenchymal Stem Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Cutaneous Wound Healing in Type 2 Diabetic Mice via Macrophage Pyroptosis Inhibition

4 citations, September 2023 in “Stem cell research & therapy”

Special particles from umbilical cord stem cells help heal skin wounds in diabetic mice by preventing certain immune cell death.

research The Hair Follicle: Functions, Self-Renewal, and Alopecic Disorders

28 citations, March 2016 in “Toxicologic pathology”

Dogs could be good models for studying human hair growth and hair loss.

research From Hair to Colon: Hair Follicle-Derived MSCs Alleviate Pyroptosis in DSS-Induced Ulcerative Colitis by Releasing Exosomes in a Paracrine Manner

1 citations, September 2022 in “Oxidative Medicine and Cellular Longevity”

Hair follicle stem cells can help treat ulcerative colitis in mice by releasing beneficial exosomes.

research Cell Death as an Architect of Adult Skin Stem Cell Niches

April 2024 in “Cell death and differentiation”

Cell death shapes skin stem cell environments, affecting inflammation, repair, and cancer.

research Gsdma3 Is Required for Hair Follicle Differentiation in Mice

30 citations, October 2010 in “Biochemical and biophysical research communications”

The Gsdma3 gene is essential for normal hair development in mice.

research N-Terminal Functional Domain of Gasdermin A3 Regulates Mitochondrial Homeostasis via Mitochondrial Targeting

76 citations, June 2015 in “Journal of biomedical science”

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

research Gasdermin A3-Mediated Cell Death Causes Niche Collapse and Precocious Activation of Hair Follicle Stem Cells

2 citations, April 2019 in “Journal of Investigative Dermatology”

Gasdermin A3 causes hair follicle stem cells to activate too early, leading to hair loss.

research Roles of GasderminA3 in Catagen–Telogen Transition During Hair Cycling

25 citations, April 2015 in “Journal of Investigative Dermatology”

GasderminA3 is important for normal hair cycle transitions by controlling Wnt signaling.

research The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier

23 citations, December 2021 in “Frontiers in Immunology”

IL-1 family cytokines are crucial for skin defense and healing, but their imbalance can cause skin diseases.

research In Vivo Response of GsdmA3Dfl/+ Mice to Topically Applied Anti-Psoriatic Agents: Effects on Epidermal Thickness, as Determined by Optical Coherence Tomography and H&E Staining

15 citations, February 2011 in “Experimental Dermatology”

Betamethasone dipropionate reduced skin thickness, fish oil increased it, and combined treatment had no significant effect.

research Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin

9 citations, August 2021 in “International journal of molecular sciences”

PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

research Decay of Skin-Specific Gene Modules in Pangolins

1 citations, May 2023 in “Journal of molecular evolution”

Pangolins have lost some skin-related genes, but kept others, leading to their unique scales and skin features.

research Convergent Decay of Skin-Specific Gene Modules in Pangolins

1 citations, December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Pangolins have lost some skin-related genes, but kept others, showing complex skin evolution.

research Aberrant Inflammasome Activation as a Driving Force of Human Autoimmune Skin Disease

3 citations, May 2023 in “Frontiers in immunology”

Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.

research Overview of Lichen Planopilaris: Diagnosis and Treatment

July 2018 in “Elsevier eBooks”

Lichen Planopilaris is a hair loss condition best treated early with various medications, including hydroxychloroquine, to prevent permanent baldness.

research Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: An Update

52 citations, October 2012 in “Journal of Dermatological Science”

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

research Hair Follicle Mesenchymal Stem Cell Exosomal LncRNA H19 Inhibited NLRP3 Pyroptosis to Promote Diabetic Mouse Skin Wound Healing

13 citations, February 2023 in “Aging”

A substance from hair follicle stem cells helps heal skin wounds in diabetic mice by promoting cell growth and preventing cell death.

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

417 citations, September 2005 in “PLoS biology”

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

research Development and Homeostasis of the Sebaceous Gland

107 citations, August 2012 in “Seminars in Cell & Developmental Biology”

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

research Sebaceous Immunobiology: Skin Homeostasis, Innate Immunity Coordination, Inflammatory Response, and Disease Associations

21 citations, November 2022 in “Frontiers in immunology”

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

research Sebaceous Gland Abnormalities in Fatty Acyl CoA Reductase 2 (Far2) Null Mice Result in Primary Cicatricial Alopecia

14 citations, October 2018 in “PloS one”

Deleting the Far2 gene in mice causes sebaceous gland issues and patchy hair loss.

research Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling

13 citations, September 2022 in “Biomolecules”

The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.

research Upregulation of Interfollicular Epidermal and Hair Infundibulum β-Catenin Expression in Gsdma3 Mutant Mice

11 citations, June 2012 in “Acta histochemica”

Mice with a Gsdma3 gene mutation have thicker skin and longer hair follicle openings due to increased β-catenin levels.

research Alopecia in Harlequin Mutant Mice Is Associated with Reduced AIF Protein Levels and Expression of Retroviral Elements

4 citations, December 2020 in “Mammalian genome”

Harlequin mutant mice have hair loss due to low AIF protein levels and retroviral element activity.

research A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells

31 citations, August 2021 in “Stem Cell Research & Therapy”

The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.