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GlossaryGasdermin family

group of proteins that trigger cell death and inflammation

The Gasdermin family is a group of proteins involved in the process of cell death and inflammation. These proteins can form pores in cell membranes, leading to a type of cell death called pyroptosis, which is important for fighting infections but can also contribute to inflammatory diseases.

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research Depletion of Gsdma1/2/3 Alleviates PMA-Induced Epidermal Hyperplasia by Inhibiting the EGFR–Stat3/Akt Pathway

6 citations , December 2023 in “Journal of Molecular Cell Biology”

Removing Gsdma1/2/3 genes reduces skin cell overgrowth by blocking a specific cell pathway.

research Sebaceous Gland Abnormalities in Fatty Acyl CoA Reductase 2 (Far2) Null Mice Result in Primary Cicatricial Alopecia

14 citations , October 2018 in “PloS one”

Deleting the Far2 gene in mice causes sebaceous gland issues and patchy hair loss.

research Hair Follicle Mesenchymal Stem Cell Exosomal LncRNA H19 Inhibited NLRP3 Pyroptosis to Promote Diabetic Mouse Skin Wound Healing

13 citations , February 2023 in “Aging”

A substance from hair follicle stem cells helps heal skin wounds in diabetic mice by promoting cell growth and preventing cell death.

research Upregulation of Interfollicular Epidermal and Hair Infundibulum β-Catenin Expression in Gsdma3 Mutant Mice

11 citations , June 2012 in “Acta histochemica”

Mice with a Gsdma3 gene mutation have thicker skin and longer hair follicle openings due to increased β-catenin levels.

research Decay of Skin-Specific Gene Modules in Pangolins

1 citations , May 2023 in “Journal of molecular evolution”

Pangolins have lost some skin-related genes, but kept others, leading to their unique scales and skin features.

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