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This review describes recent advances in the study of epidermal stem cells and their importance in regenerative medicine and skin tissue engineering, but provides no new clinical results.

This study identified and isolated highly proliferative canine keratinocytes in vitro, finding that follicular keratinocytes showed distinct proliferative capacity and marker expression indicative of putative epithelial stem cells.

The researchers reported that basal cell carcinoma tumor cells strongly express keratins typical of basal keratinocytes and some hair follicle components but lack differentiation markers, suggesting a follicular or pluripotent stem cell origin.

This study found that K15 is a useful marker for investigating the role of stem cells in canine hair follicle tumours, while nestin is not optimal.

This study found that treating hair follicular stem cells with tissue extract from 10-day-old mouse embryos significantly enhanced their differentiation into neural cells, particularly with higher extract concentrations.

In this study, researchers observed that hybrid secretomes most effectively stimulated proliferation and stem cell markers for hair regeneration in hamster skin, while human secretomes strongly activated the Wnt/β catenin pathway, suggesting different underlying mechanisms among the tested formulations.

In a testosterone-induced mouse model of androgenetic alopecia, this study found that oral and topical administration of Connarus semidecandrus Jack ethanol extract promoted hair regrowth and improved hair health markers similar to finasteride, without detectable liver or kidney toxicity.

In a mouse model, this study found that exposure to PM2.5 leads to significant postpartum hair loss, apparent via morphological changes and elevated markers of inflammation, apoptosis, and fibrosis, potentially exacerbated by changes in hormone receptors and stem cell populations.

In this study, topical latanoprost acid applied daily for 6 months increased hair count and improved trichoscopic markers among women with hair loss, suggesting its potential for treating female androgenetic alopecia, particularly at a 0.05% concentration.

This study identified changes in immune activation, ferroptosis, and structural genes in alopecia areata subtypes, suggesting molecular markers that might help understand disease variability and guide future treatments.

This study found that calretinin immunoreactivity may help identify the innermost cell layer of the outer root sheath in anagen hair follicles and certain cutaneous adnexal proliferations with follicular, sebaceous, and eccrine differentiation.

In this study, researchers using a UVB-induced mouse model identified the gene COL7A1 as a novel marker for hair luster, finding that minoxidil, caffeine, and biotin effectively restored its expression, indicating potential therapeutic strategies.

This study found that cutaneous stem cells in the basal layer of fetal human skin contribute to the development of the epidermis and hair follicles, with specific marker expressions during different stages of skin development.

In this study, researchers identified hair follicle stem cells in the bulge region of canine hair follicles, suggesting potential applications for future translational research.

This review discusses the role of stem cells in the hair follicle bulge region for regenerative medicine and reports no new clinical results; the authors highlight the complexities in studying these cells' involvement in alopecia.

This study found that in identifying bulge stem cells, CD34 is more specific in mice and CD200 in humans, with CD200 potentially marking progenitor and partially differentiated cells.

In this study, researchers linked SARS-CoV-2 infection to telogen effluvium in some COVID-19 patients by observing the accumulation of viral proteins in hair follicle cells, which may trigger stress responses and cell death, suggesting hair follicles as a potential target in COVID-19.

The study found that CK15 expression, representing hair follicle stem cell activity, was reduced or absent in scarred primary cicatricial alopecia lesions, suggesting stem cell damage may contribute to the scarring process.

This study suggests that damage to stem cells in the bulge region of hair follicles may contribute to scarring in chronic cutaneous lupus erythematosus.

This review discusses the clonal or polyclonal nature of skin carcinomas and the stem cell origins of basal and squamous cell carcinomas but presents no new research findings.

This study found that keratin 15 expression in trichoepitheliomas and some basal cell carcinomas suggests a link to hair follicle stem cells in the bulge.

This study found that cyclosporin A treatment enhances hair growth in mice by inhibiting calcineurin-NFAT1 activity, which alters keratinocyte differentiation and apoptosis-related gene expression in hair follicles.

This study found that CD45RO+ cells, a subtype of T lymphocytes, were notably reduced in the ovarian follicles of women with PCOS, which may contribute to the condition's pathogenesis.

This study found that deleting Stim1 and Stim2 in mature T regulatory cells disrupts Ca 2+ signaling, preventing their differentiation and leading to severe autoimmune disorders in mice.

This systematic review suggests that intraoperative corticosteroids can reduce postoperative edema in FUE hair transplantation donor areas, but highlights a need for more mechanistic studies to improve understanding of tissue regeneration.

This article discusses the kinetic and topographical heterogeneity in follicular thyroid neoplasms and reports no new research findings; the authors emphasize understanding diverse growth patterns.

In this study, researchers found that the number of dermal papilla cells in hair follicles determines hair size and shape in mice, suggesting potential avenues for addressing hair loss.

This study found that nanocapsules formulated as a dispersion and applied with massage may enhance follicular uptake of clobetasol propionate while minimizing its skin penetration, offering a potential improvement over conventional treatments for scalp diseases.

This study developed a 3D engineered hair follicle model that mimics the native hair bulb and may aid in drug screening for hair growth therapies.

Human hair follicle stem cells show signs of low oxygen levels, which may be important for hair growth and preventing baldness.