Hair Follicle Stem Cells in the Pathogenesis of Primary Cicatricial Alopecia

    March 2015 in “ Zagazig University Medical Journal ”
    Enas Al-Makhzangy, Manal Elsayed, Magda Assaf, abdulla esawy
    TLDR Damage to hair follicle stem cells may cause permanent hair loss and scarring in PCA.
    The study investigated the role of epithelial hair follicle stem cells in the scarring process of primary cicatricial alopecia (PCA) by examining skin biopsies from 40 patients with various forms of PCA. The research focused on the expression of cytokeratin 15 (CK15), a marker for hair follicle stem cells, and its correlation with inflammatory cell infiltrate. Results showed that CK15 expression was absent in scarred PCA and weak or absent in cases of severe inflammation, suggesting damage to stem cells or their differentiation for repair. This damage to follicular stem cells might explain the irreversible alopecia and scarring characteristic of PCA.
    Discuss this study in the Community →

    Research cited in this study

    13 / 13 results

    Related Community Posts Join

    6 / 429 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  56 upvotes 7 months ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  99 upvotes 8 months ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

      community Can we get a reality check on PP405?

      in Research/Science  76 upvotes 3 weeks ago
      PP405 is a promising hair loss treatment that may outperform minoxidil and finasteride by reviving dormant follicles and promoting significant regrowth. Results from ongoing trials are awaited, with a potential market release between 2028-2030.

    Similar Research

    5 / 1000+ results