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GlossaryPermanent Alopecia (irreversible alopecia)

permanent hair loss due to damaged or destroyed hair follicles

Permanent Alopecia, also known as irreversible alopecia or permanent hair loss, refers to the long-term or lifelong loss of hair from the scalp or other parts of the body. This condition can result from various causes, including genetic factors (such as androgenetic alopecia), scarring from injuries or medical treatments (like radiation therapy), and certain autoimmune diseases (such as alopecia areata that progresses to a scarring form). Unlike temporary hair loss, the hair follicles in permanent alopecia are often damaged or destroyed, making regrowth impossible.

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Irreversible Alopecia Universalis During Treatment With Pegylated Interferon-Ribavirin for Chronic Hepatitis C Virus Infection: Case Report and Literature Review

research Irreversible Alopecia Universalis During Treatment With Pegylated Interferon-Ribavirin for Chronic Hepatitis C Virus Infection: Case Report and Literature Review

9 citations , November 2012 in “Hepatology Research”

A man lost all his hair permanently after hepatitis C treatment, a side effect not seen before.

research Irreversible And Severe Alopecia Following Docetaxel Or Paclitaxel Cytotoxic Therapy For Breast Cancer

61 citations , April 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Docetaxel and paclitaxel for breast cancer can cause permanent, severe hair loss.

research Hair Follicle Stem Cells in the Pathogenesis of Primary Cicatricial Alopecia

March 2015 in “Zagazig University Medical Journal”

Damage to hair follicle stem cells may cause permanent hair loss and scarring in PCA.

research Hot Comb Alopecia

107 citations , September 1968 in “Archives of Dermatology”

Using hot combs can cause permanent hair loss on the scalp's crown.

research Frontal Fibrosing Alopecia: A Review of Disease Pathogenesis

2 citations , July 2022 in “Frontiers in Medicine”

The cause of Frontal fibrosing alopecia, a type of hair loss, is complex, likely involving immune responses and genetics, but is not fully understood.

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community The Real Cause Of Androgenetic Alopecia

in Research/Science 680 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community scarring alopecia awareness in this community

in Chat 33 upvotes 3 years ago

Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

community any news about DUPA (Diffuse unpatterned alopecia)?

in Research/Science 8 upvotes 3 years ago

The conversation discusses diffuse unpatterned alopecia (DUPA) and its possible causes, including sensitivity to DHT, not being androgenic alopecia, being diffuse alopecia areata, or hormonal issues. Treatments mentioned include topical melatonin, Clobetasol Propionate for alopecia areata, and the lack of results from using finasteride, dutasteride, and minoxidil.

community My Theory Of Androgenic Alopecia

in Research/Science 17 upvotes 3 weeks ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 99 upvotes 5 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

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