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Glossary Puberty Blockers

medications that delay the physical changes of puberty

Puberty blockers, also known as puberty inhibitors or hormone blockers, are medications that delay the physical changes associated with puberty. They work by suppressing the release of sex hormones like estrogen and testosterone, which can be particularly beneficial for transgender and non-binary youth who need more time to explore their gender identity before undergoing irreversible physical changes. These medications are also used in cases of precocious puberty to prevent early onset of puberty.

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Research

5 / 1000+ results

research Endocrine Treatment of Transsexual Persons:An Endocrine Society Clinical Practice Guideline

855 citations , June 2009 in “The Journal of Clinical Endocrinology & Metabolism”

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

research Clinical Management of Youth with Gender Dysphoria in Vancouver

116 citations , December 2013 in “The Journal of Pediatrics”

This study reported that treatment with gonadotropin-releasing hormone analogs and cross-sex hormones appears appropriate for carefully selected youth with gender dysphoria, but long-term safety needs further investigation.

research Progress on the road to better medical care for transgender patients

66 citations , October 2013 in “Current Opinion in Endocrinology, Diabetes and Obesity”

This review offers transgender hormone treatment guidelines to assist healthcare providers in improving transgender patients' access to and outcomes of medical care, but it reports no new clinical results.

research Endocrine care of transpeople part I. A review of cross-sex hormonal treatments, outcomes and adverse effects in transmen

45 citations , March 2015 in “Clinical Endocrinology”

This article reviews the use of cross-sex hormonal therapy in transmen and reports that it is reasonably safe, suggesting monitoring should be frequent initially but can be less frequent over time.

research Gonadal Suppressive and Cross‐Sex Hormone Therapy for Gender Dysphoria in Adolescents and Adults

25 citations , September 2014 in “Pharmacotherapy”

This review covers cross-sex hormone therapy for gender dysphoria, noting improvements in psychological symptoms and quality of life but lacking definitive long-term safety data.

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Community Join

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community 27M Seeking Non-DHT Blocker Alternatives After Minoxidil and Finasteride Issues

in Treatments 159 upvotes 7 months ago

A user is seeking hair loss treatments without using systemic DHT blockers like finasteride due to side effects. Suggestions include clascoterone (not FDA approved), pyrilutamide, RU58841, and low-dose topical finasteride, with a recommendation to consult a doctor.

community Why are hormone blockers more socially acceptable than hair systems or balding?

in Chat 105 upvotes 6 months ago

Finasteride is more accepted than hair systems because it is less visible and maintains natural hair. Treatments like minoxidil and finasteride are commonly used for hair loss, but opinions on hair systems vary.

community Iron D3 levels actually matter more else dht blockers wont work(yes they can keep follicle alive)

77 upvotes 1 year ago

Taking finasteride alone did not stop hair loss, but adding vitamin D3 and iron supplements improved hair coverage and quality. It's important to check and address deficiencies, but caution is advised with iron supplementation without medical guidance.

community Regrowth after 9 months of DHT blockers, and 6 months of HRT

in Transgender 24 upvotes 10 months ago

A 20-year-old saw significant hair regrowth after 9 months of using DHT blockers (finasteride and dutasteride) and 6 months of hormone replacement therapy (HRT) with estradiol. The regrowth is attributed to low testosterone and high estradiol levels, without using Minoxidil.

community Anyone have experience with natural DHT blockers?

7 upvotes 2 years ago

The conversation is about using natural DHT blockers like pumpkin seed oil and saw palmetto extract for hair loss. The user has been using minoxidil, derma rolling, vitamin D, and biotin but is considering finasteride next.

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