Role of Follicular Stem Cells in the Pathophysiology of Alopecia Areata

July 2015

Danijel Sumajstorčić

alopecia areata hair follicles stem cells bulge region multipotent stem cells epidermis sebaceous glands non-scarring alopecia scarring alopecia keratin 15 CD34 CD200 inflammatory damage autoaggressive immunity immune protection genetic predisposition

TLDR Alopecia areata is reversible because hair follicles can regenerate due to stem cells.

The document discussed the role of follicular stem cells in the pathophysiology of alopecia areata. It highlighted that the discovery of stem cells in the bulge region of hair follicles spurred research into their potential use in regenerative medicine. These multipotent stem cells could differentiate into various cell types, aiding in epidermal regeneration. The study noted that while some inflammatory conditions cause permanent hair loss, alopecia areata is reversible due to the regenerative capacity of affected follicles. The research on follicular stem cells advanced with the identification of molecular markers like keratin 15 and CD200, facilitating their isolation and study. The pathogenesis of alopecia areata involved inflammatory damage to stem cells, with the hair follicle being a target of autoimmune reactions, influenced by environmental factors and genetic predisposition.

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