TLDR Stem cells play a key role in nonmelanoma skin cancers, with different origins and genetic changes linked to basal and squamous cell carcinomas.
The document discussed the role of stem cells in nonmelanoma skin cancers, specifically squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). It highlighted that SCC and BCC are clonal, while focal hyperplasias are polyclonal. Stem cells in the skin, particularly those in the hair follicle bulge, were identified as multipotent, capable of differentiating into various epidermal cells. BCCs were linked to follicular bulge stem cells and genetic changes in the Sonic Hedgehog pathway, while SCCs could originate from stem cells in different skin compartments, including the interfollicular epidermal proliferative unit (EPU). The study also noted that genetic or epigenetic changes in stem cell markers, such as integrins and telomerase, were associated with squamous cell neoplasms.
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