Kinetic Topographical Heterogeneity in Follicular Thyroid Neoplasms and Growth Patterns

The document examined the cell proliferation and death in different types of follicular thyroid neoplasms, including 43 follicular thyroid adenomas (FTA), 28 minimally invasive follicular thyroid carcinomas (MI-FTC), 48 widely invasive follicular thyroid carcinomas (WI-FTC), and 27 anaplastic thyroid carcinomas (ATC). The study found that benign lesions showed higher cell proliferation and lower cell death internally, while malignant lesions had these features at their periphery. This was evidenced by a significant decrease in apoptosis in the internal compartments of adenomas and in the peripheral compartments of carcinomas. The findings suggest that the growth patterns of these tumors, such as encapsulation in benign tumors and invasiveness in malignant ones, are influenced by the location of cell proliferation and death within the tumor.