Co-Secretion of Testosterone and Cortisol by a Functional Adrenocortical Oncocytoma

    August 2007 in “ Histopathology ”
    R Logasundaram, Christine E. Parkinson, Peter J. Donaldson, P E Coode
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    TLDR A woman's rare adrenal tumor caused high testosterone and cortisol levels, which normalized after the tumor was removed.
    In 2007, a 58-year-old woman with symptoms including male pattern hair loss was diagnosed with elevated testosterone and cortisol levels due to a functional adrenocortical oncocytoma, a rare type of usually non-functional adrenal tumor. Imaging showed a mass on her right adrenal gland, and a low-dose dexamethasone suppression test indicated low-grade Cushing's syndrome. Post right laparoscopic adrenalectomy, her hormone levels returned to normal, and she received hydrocortisone treatment to prevent hypoadrenalism. The patient's blood pressure and glycemic control improved after surgery. This case contributes to the scarce literature on hormonally active adrenocortical oncocytic tumors that secrete both testosterone and cortisol.
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