5 citations,
July 2022 in “Orphanet journal of rare diseases”
RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.
Topical finasteride and minoxidil, combined with microneedling, are recommended for treating thinning hair areas, with 1-2 sprays daily being effective and having fewer side effects than oral finasteride. Starting microneedling at 1.0mm is advised for effectiveness while minimizing invasiveness.