Human Secretomes, Plant Exosomes, And Hybrid Secretomes Intradermal Injections For Hair Regeneration: Experimental Study

    August 2026 in “ Plastic & Reconstructive Surgery Global Open ”
    Noury Adel, Jack Kolenda, Jesper Thulesen … Jose Ramon Saucillo
    Studysummary In this study, researchers observed that hybrid secretomes most effectively stimulated proliferation and stem cell markers for hair regeneration in hamster skin, while human secretomes strongly activated the Wnt/β catenin pathway, suggesting different underlying mechanisms among the tested formulations.
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    Research cited in this study 11

    1. Regulation of Melanin Synthesis in Goat Hair Follicles by Melatonin Through the Wnt/β-Catenin Pathway Molecular Genetics and Genomics · 2025
    2. Exosomes And Hair Regeneration: A Systematic Review Of Clinical Evidence Across Alopecia Types And Exosome Sources Clinical Cosmetic and Investigational Dermatology · 2025
    3. Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Enhance Follicular Regeneration in Androgenetic Alopecia via Activation of Wnt/β-Catenin Pathway Stem Cell Research & Therapy · 2025
    4. Therapeutic Potential of Isoproterenol in Androgenetic Alopecia: Activation of Hair Follicle Stem Cells via the PI3K/AKT/β-Catenin Signaling Pathway Stem Cell Research & Therapy · 2025
    5. Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions PubMed · 2025
    6. Highlights From JAAD Reviews: August 2025—Bicalutamide for Female Hair Loss Journal of the American Academy of Dermatology · 2025
    7. Hyperbranched Polymer Dots Enhance Hair Follicle Regeneration via Wnt/β-Catenin Activation: A Drug-Free Nanozyme-Based Approach to Hair Growth Therapy Biomedicine & Pharmacotherapy · 2025
    8. Oxyresveratrol Enhances Hair Regeneration in Human Dermal Papilla Cells and Androgenetic Alopecia Mouse Model Scientific Reports · 2025
    9. Enhanced Therapeutic Effects of All-Trans Retinoic Acid Nanostructured Lipid Carrier Composite Gel Drug Delivery System for Alopecia Areata Journal of Nanobiotechnology · 2025
    10. Mesenchymal Stem Cell Exosomes Enhance the Development of Hair Follicle to Ameliorate Androgenetic Alopecia World Journal of Stem Cells · 2025
    11. Human Hair Follicle Mesenchymal Stem Cell-Derived Exosome Attenuates UVB-Induced Photoaging Via The miR-125b-5p/TGF-β1/Smad Axis Biomaterials Research · 2024