Hyperbranched Polymer Dots Enhance Hair Follicle Regeneration via Wnt/β-Catenin Activation: A Drug-Free Nanozyme-Based Approach to Hair Growth Therapy

The study explores the effects of Hyperbranched Polymer Dots (HPD) on hair regrowth in C57BL/6 mice, focusing on Wnt/β-catenin activation. Conducted with 24 mice divided into four groups, including a control and minoxidil group, the research found that high-dose HPD significantly accelerated hair regrowth, achieving 94.1% coverage by day 16, surpassing both low-dose HPD and minoxidil. HPD treatment also led to earlier anagen phase entry and increased skin pigmentation. The study suggests HPD as a promising non-invasive therapy for hair growth, with advantages over current treatments like minoxidil, though further research is needed for long-term safety and human applicability.