Hollow Polydopamine Nanoparticles Loading with Peptide RL-QN15: A New Pro-Regenerative Therapeutic Agent for Skin Wounds

    October 2021 in “ Journal of Nanobiotechnology ”
    Huiling Sun, Ying Wang, Tiantian He, Dingwei He, Yan Hu, Zhe Fu, Yinglei Wang, Dandan Sun, Junsong Wang, Yixiang Liu, Longjun Shu, Li He, Ziwei Deng, Xinwang Yang
    TLDR HPDAlR nanoparticles greatly improve skin wound healing without toxicity.
    The study explored the use of hollow polydopamine (HPDA) nanoparticles loaded with the peptide RL-QN15 (HPDAlR) as a pro-regenerative therapeutic agent for skin wounds. HPDAlR significantly enhanced wound healing in various animal models, including mice, rats, and swine, compared to RL-QN15 alone. The nanoparticles improved the peptide's pro-regenerative potency by enhancing loading and slow-release capabilities, which promoted cytokine release and accelerated healing. In mice, HPDAlR achieved a 99.24% repair rate for scald wounds, and in rats, it accelerated oral ulcer healing to 5 days. In swine, it improved the healing rate of full-thickness skin wounds to 87.52% by day 28. The study concluded that HPDAlR could be a promising therapeutic agent for skin wounds, with further exploration needed for clinical applications.
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