Hollow Polydopamine Nanoparticles Loading with Peptide RL-QN15: A New Pro-Regenerative Therapeutic Agent for Skin Wounds

    October 2021 in “ Journal of Nanobiotechnology ”
    Huiling Sun, Ying Wang, Tiantian He, Dingwei He, Yan Hu, Zhe Fu, Yinglei Wang, Dandan Sun, Junsong Wang, Yixiang Liu, Longjun Shu, Li He, Ziwei Deng, Xinwang Yang
    TLDR HPDAlR nanoparticles greatly improve skin wound healing without toxicity.
    The study investigated the use of hollow polydopamine (HPDA) nanoparticles loaded with the peptide RL-QN15 (HPDAlR) as a new pro-regenerative therapeutic agent for skin wounds. The research demonstrated that HPDAlR significantly enhanced the healing ability of RL-QN15, increasing its pro-regenerative potency by 50 times in mice and 10 times in rats compared to RL-QN15 alone. The nanoparticles showed no toxicity and improved the healing of keratinocyte scratches and modulated cytokine release from macrophages. HPDAlR also enhanced the healing efficiency in animal models of skin scalds and full-thickness wounds, indicating its potential as a therapeutic agent for skin wound healing.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 18 results

      community Does DHT give you a leaner face?

      in Finasteride/Dutasteride  44 upvotes 9 months ago
      Finasteride and dutasteride may increase estrogen levels, leading to water retention and a fuller face. Users discuss managing these effects with lifestyle changes and supplements like zinc and DIM.

      community 6 weeks minoxidil… and spironolactone

      in Progress Pictures  36 upvotes 2 months ago
      Minoxidil and spironolactone are used for hair regrowth, with visible progress noted. Spironolactone is discussed as a treatment option, particularly in the context of transitioning, with concerns about its effects on men.

      community Doctor said I was screwed: 3 months update

      in Progress Pictures  263 upvotes 3 months ago
      After 3 months of using minoxidil and finasteride, OP experienced significant hair regrowth despite initial skepticism from their doctor. Many users commented on the impressive progress and discussed the common issue of posting "after" pictures before "before" pictures.

      community Why nobody uses 0.25% (2.5mg/ml)?

      in Treatment  66 upvotes 1 year ago
      The conversation is about the effectiveness of 0.25% topical finasteride compared to other concentrations and forms. Users discuss its potential for better scalp DHT reduction and fewer side effects, with some preferring topical over oral treatments.

    Similar Research

    5 / 477 results