Insights Into the Angiogenic Effects of Nanomaterials: Mechanisms Involved and Potential Applications

The document reviewed the angiogenic effects of nanomaterials, emphasizing their potential in tissue engineering and regenerative medicine due to their unique properties. It discussed how nanomaterials, such as nanoparticles and nanofibres, could mimic the extracellular matrix, enhance endothelial cell behavior, and serve as delivery vectors for proangiogenic factors. The study highlighted the importance of understanding the physicochemical properties of nanomaterials, such as surface modifications, stiffness, and wettability, to optimize their angiogenic effects. It also noted the role of nanomaterials in various applications, including bone tissue engineering, skin wound healing, nerve tissue repair, and cardiovascular applications. Despite promising results, the document stressed the need for further research on the long-term safety and optimization of nanomaterials for clinical use.