Regulation of Melanin Synthesis in Goat Hair Follicles by Melatonin Through the Wnt/β-Catenin Pathway
October 2025
in “
Molecular Genetics and Genomics
”
Research cited in this study
8 / 8 results
research Melatonin Promotes Hair Regeneration by Modulating the Wnt/β-Catenin Signaling Pathway
This study found that melatonin supplementation significantly promoted hair regeneration in a hair depilation mouse model by up-regulating the Wnt/β-catenin signaling pathway in dermal papillae and hair follicle stem cells, suggesting potential implications for human hair loss treatments.
research Revisiting the Role of Melatonin in Human Melanocyte Physiology: A Skin Context Perspective
This review examines melatonin's potential effects on human skin and hair follicle pigmentation, highlighting the need to confirm findings from cell cultures in physiological tissue contexts.
research Wnt/β-Catenin Signaling: Function, Biological Mechanisms, and Therapeutic Opportunities
This study systematically reviews the Wnt/β-catenin signaling pathway, discussing its origin, composition, function, involvement in tumors and diseases, and the development of small-molecular compounds targeting this pathway for disease treatment.
research Wnt/β-Catenin Signaling Pathway Activates Melanocyte Stem Cells In Vitro and In Vivo
This study found that the Wnt/β-catenin signaling pathway activates melanocyte stem cells, promoting hair follicle regeneration both in vitro and in vivo.
research Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation
This review discusses the identification and characteristics of melanocyte stem cells, emphasizing their role in hair pigmentation, greying, and skin repigmentation, but reports no new research findings.
research Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells
COL17A1 is crucial for preventing hair graying and loss by supporting hair and pigment stem cells.
research The Hair Follicle as a Dynamic Mini-Organ
This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.
research Melatonin and the Hair Follicle
This study suggests that melatonin plays a role in hair follicle function by modulating growth and pigmentation, and it may act as a protective agent in active hair growth phases.
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research Melatonin promotes proliferation of Inner Mongolia cashmere goat hair follicle papilla cells through Wnt10b
This study found that melatonin promotes the growth of secondary hair follicles in Inner Mongolian cashmere goats by enhancing the activity and proliferation of dermal papilla cells through involving the Wnt10b gene, though the detailed mechanisms remain undetermined.
research Alteration of hair growth in mice by circulating exosomes from Xinji fine-wool and small-tailed Han sheep
In this study, researchers found that circulating exosomes from different sheep breeds can significantly alter hair growth in mice, with the source of exosomes influencing hair follicle size and hair diameter, as well as expression of specific hair growth and melanin synthesis markers.
research Involvement of DKK1 secreted from adipose‐derived stem cells in alopecia areata
This study found that adipose-derived stem cells with DKK1 knocked out using CRISPR/Cas9 promoted hair growth in an alopecia areata model more effectively than untreated stem cells, suggesting DKK1 is a potential therapeutic target for this condition.
research Modeling of solar UV-induced photodamage on the hair follicles in human skin organoids
In this study, researchers used a human skin organoid model to show that solar UV exposure damages hair follicles and skin, while exosomes from mesenchymal stem cells reduced inflammation and supported hair follicle regeneration.
research B-Raf and C-Raf Are Required for Melanocyte Stem Cell Self-Maintenance
In this study, knockout of B-raf and C-raf genes in mice showed they are not needed for early melanocyte development, but are crucial for maintaining melanocyte stem cells, as evidenced by hair graying due to stem cell depletion.