B-Raf and C-Raf Are Required for Melanocyte Stem Cell Self-Maintenance

    September 2012 in “ Cell Reports ”
    Agathe Valluet, Sabine Druillennec, Céline Barbotin … Alain Eychène
    Studysummary In this study, knockout of B-raf and C-raf genes in mice showed they are not needed for early melanocyte development, but are crucial for maintaining melanocyte stem cells, as evidenced by hair graying due to stem cell depletion.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on cell.com →
    Discuss this study in the Community →

    Research cited in this study 3

    1. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    2. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    3. Melanoblasts' Proper Location and Timed Differentiation Depend on Notch/RBP-J Signaling in Postnatal Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008

    Related research 4

    1. Casein Kinase 1 Inhibition in Keratinocytes Enhances the Migration of Melanocyte Precursors in the Hair Follicle via KitL/c-Kit Signaling Pathway Journal of Investigative Dermatology · 2023
    2. Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation Pigment Cell & Melanoma Research · 2011
    3. Functionally Distinct Melanocyte Populations Revealed by Reconstitution of Hair Follicles in Mice Pigment Cell & Melanoma Research · 2010
    4. Aging of the Hair Follicle Pigmentation System International journal of trichology · 2009