5 citations
,
November 2005 This review discusses the applications of confocal laser scanning microscopy in visualizing fluorescent compounds within the skin, noting its potential for tracking drug carriers and enhancing penetration studies, but reports no new results.
19 citations
,
April 2013 in “Drug Development and Industrial Pharmacy” This study highlights the significance of the hf pathway for the skin permeation of ionized and hydrophilic high molecular compounds, and the usefulness of hf-plugging in evaluating their skin permeability.
119 citations
,
December 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, transcutaneously applied nanoparticles and viral vectors were shown to penetrate murine hair follicles, internalize in antigen-presenting cells, and induce immune responses, suggesting a promising approach for vaccine delivery.
3 citations
,
October 2018 in “Revista de Chimie” This review discusses the potential medicinal properties and pharmacokinetic features of nettle compounds ursolic acid and quercetin, highlighting quercetin as a promising candidate for antioxidant and anti-aging effects, but reports no new clinical results.
9 citations
,
March 2017 in “Journal of Visualized Experiments” This study introduced a novel in vitro murine assay using transgenic mice to identify immunomodulatory compounds, which identified 160 potential hits from 4,398 compounds screened.
2 citations
,
November 2025 in “Pharmaceutics” This study found that a CLSM-based approach could semi-quantitatively assess the transdermal penetration behavior of fluorescent dyes with different lipophilicities, offering a tool for early-stage screening of compound penetration.
December 2022 in “Ecological Chemistry and Engineering S” This study synthesized indole-acenaphthylene compounds using a magnetic nanocatalyst and explored their photoluminescence properties for detecting copper ions in a mixed solvent system, achieving a detection limit of 9.5 ∙ 10 –6 M.
January 2012 in “RepositóriUM (Universidade do Minho)” This study reported that a modified nanoprecipitation protocol can effectively create PLA nanoparticles capable of delivering compounds into hair follicles, with promising potential for hair follicle therapy and cosmetic applications.
17 citations
,
March 2005 in “Journal of Investigative Dermatology” This study found that human hair follicle bulge stem cells exhibited autofluorescence, potentially due to high flavin- and NAD-related compound levels, highlighting the need to consider this when using fluorescent antibodies for studying these cells.
5 citations
,
January 2018 This study optimized a screening assay to identify molecules that inhibit or enhance TRPM5 ion channel activity, which may have implications for treating dysfunctions linked to cardiac arrhythmias and diabetes.
January 2025 in “Analytical Methods” This study reports the development of a fluorescent ionic liquid that shows high sensitivity and selectivity for detecting dextran sulfate sodium, with potential applications in clinical diagnostics and environmental monitoring.
67 citations
,
January 2012 in “Biological and Pharmaceutical Bulletin” This study found that nanoparticles did not permeate intact rat skin but could penetrate skin that had been artificially punctured, primarily through grooves or hair follicles.
2 citations
,
November 2022 in “Biosensors” This study introduced a new spectrofluorometric method using a synthesized organic fluorophore to effectively analyze darolutamide and thalidomide in pharmaceutical preparations and biofluids.
March 2005 in “International Journal of Cosmetic Science” This paper discusses the use of Digital Volumetric Imaging with fluorescent dyes to visualize and compare the interior structures of six different virgin hair types, reporting no new clinical results.
January 2024 in “Wiadomości Lekarskie” This study reported the development of fluorescent markers using wide band gap metal oxides with rare earth ions for early tumor detection and treatment. Testing in animals showed high efficiency and selectivity, with potential applications in contrast-enhanced MRI, targeted drug delivery, and photodynamic cancer therapy.
25 citations
,
June 2015 in “Clinical, Cosmetic and Investigational Dermatology” This study found that using an electrical microneedling device enhanced the penetration of liposomal melanin-fluorescein into hair structures and widened the follicular infundibulum in ex vivo human skin models.
November 2025 in “Advanced Healthcare Materials” This study found that incorporating CTA2-BADG, a modified hair-rebonding compound, into damaged hair significantly improved surface morphology and tensile strength by using charge-conversion chemistry to enhance penetration into the hair shaft.
5 citations
,
March 2017 in “Immunology and Cell Biology” This review discusses recent advances in biomedical imaging for cancer research, particularly highlighting improved imaging tools for studying solid tissue malignancies, and reports no new clinical results.
July 2022 in “Journal of Investigative Dermatology” This study found that a new alcohol-free minoxidil hydrogel formulation showed comparable in vitro efficacy and skin absorption to the commercial minoxidil product for treating androgenetic alopecia.
36 citations
,
August 2020 in “Polymers” The researchers developed semi-dissolving microneedle patches using TEMPO-oxidized bacterial cellulose nanofibers, which allow effective transdermal drug delivery by forming micro-channels for large drug quantities, overcoming traditional microneedles' low drug loading.
18 citations
,
January 2015 in “Data series” This report describes a study of estuarine bed-sediment quality in New Jersey and New York post-Hurricane Sandy, focusing on contamination extent and potential long-term impacts, with no new findings included.
8 citations
,
March 2020 in “Frontiers in Cell and Developmental Biology” This study developed a DPC cell line by introducing mutant CDK4, Cyclin D1, and TERT, making it a promising tool to study downstream signaling pathways activated by testosterone in androgenetic alopecia.
1 citations
,
May 2020 in “Beilstein Journal of Organic Chemistry” This study developed a novel smart deoxyribozyme-based fluorescent sensor that efficiently detects androgen receptor mRNA with high selectivity and can be adapted to target various nucleic acid sequences.
6 citations
,
December 2015 in “International journal of nanomedicine” This study found that low-frequency sonophoresis significantly decreased the skin penetration of sodium fluorescein-loaded PEGylated liposomes with D-limonene and affected percutaneous absorption by partially plugging hair follicle orifices.
31 citations
,
July 2004 in “Molecular Medicine” This study found that mutant glucocorticoid receptors have defective transcriptional activity and dynamic motility issues in the nucleus, likely due to impaired interactions with nuclear molecules necessary for gene activation.
10 citations
,
June 2014 in “Journal of Pharmacy and Pharmacology” This study found that antiandrogenic compounds in Curcuma aeruginosa, including germacrone, degrade rapidly at high temperatures but are more stable when solubilized in PEG-40.
November 2023 in “Research Square (Research Square)” In this study, researchers used NIR-II fluorescence imaging to track the survival and migration of EPI-NCSCs in rat models, finding that these stem cells aided in repairing facial nerve defects when applied via acellular nerve allografts.
January 2026 in “Dermatology and Therapy” This study suggests that using UVFD to examine non-pigmented facial lesions can potentially enhance diagnostic accuracy and reduce unnecessary biopsies.
2 citations
,
April 2021 in “International Journal of Pharmaceutics” This study concluded that a liquid serum formulation delivered two fluorescent dyes to deeper follicular regions more effectively than nanoparticle systems.
5 citations
,
November 2020 in “Frontiers in Cell and Developmental Biology” This study introduced a simple and reliable in vitro assay capable of large-scale simultaneous screening of hair growth-promoting compounds using a 3D co-culture system of human dermal papilla and outer root sheath cells.