Selective Sensing of Darolutamide and Thalidomide in Pharmaceutical Preparations and in Spiked Biofluids

    November 2022 in “ Biosensors ”
    Wael Talaat, Abdelbasset A. Farahat, Reda Mohammed Keshk
    Image of study
    TLDR A new, efficient method has been developed to detect darolutamide and thalidomide, drugs used for certain hair loss and prostate cancer treatments, in pharmaceuticals and body fluids.
    The document introduces a new, cost-effective, and less time-consuming fluorescence sensing method for detecting darolutamide and thalidomide, drugs used in treating androgen-dependent diseases like androgenic alopecia and prostate cancer. The method involves the synthesis of a compound, 2,4,8,10-Tetramethylpyrido[2′,3′:3,4]Pyrazolo[1,5-a]Pyrimidine 2, which is used in the fluorescence sensing method. The fluorescence intensity of this compound is inversely proportional to the drug concentration, with the highest intensity observed at a pH of 7.2 and a reagent volume of 1.25 mL. The method was validated and found to be accurate, precise, and robust. It was successfully applied to pharmaceutical preparations and spiked biofluids, with satisfactory recovery percentages for darolutamide and thalidomide determination in raw material and dosage forms. This method can be used in quality control and bioavailability laboratories.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 10 results

      community Anyone wanna try and interview the developers of RU?

      in Research/Science  83 upvotes 3 years ago
      The conversation discusses arranging an interview with the developers of RU58841 to clarify its safety and reasons for halted research, with some users expressing concerns about potential risks and others citing financial reasons for the discontinuation of studies. Specific treatments mentioned include RU58841, minoxidil, and finasteride.

      community Using Antihypertensive drugs for hair loss

      in Chat  6 upvotes 2 years ago
      The conversation discusses the potential connection between baldness, heart disease, and high blood pressure. Treatments mentioned include Minoxidil, Spironolactone, and Finasteride.

      community No side effects on pyrilutamide / KX-826 so far

      in Research/Science  207 upvotes 3 years ago
      User TopBack56 and friends tried pyrilutamide (KX-826) for hair loss without experiencing negative side effects. They observed fine vellus hairs but no thick hair growth yet, and plan to add GT20029 to their regime after safety trials.

      community CB-03-01 supposed hair loss cure

      in Treatment  8 upvotes 3 years ago
      The conversation discusses why CB-03-01, a potential hair loss treatment, isn't widely discussed despite evidence of its effectiveness and safety. Some users mention other treatments like melatonin, procianidin b2, and RU58841, debating their effectiveness and safety.

    Similar Research

    5 / 17 results