Synthesis and Application of Clinically Approved Small-Molecule Drugs Targeting Androgen Receptor

    November 2023 in “ Bioorganic Chemistry ”
    Hua Gao, Jingyi Zhang, Lijie Zhao, Yuanyuan Guo
    Studysummary This review provides an overview of clinically approved small molecule drugs targeting androgen receptors and discusses therapeutic applications, without presenting new experimental results.
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    Research cited in this study 7

    1. Clascoterone: First Approval Drugs · 2020
    2. Gender-Affirming Hormone Therapy for Transgender Females Clinical Obstetrics and Gynecology · 2018
    3. Use of Ethinylestradiol/Drospirenone Combination in Patients with Polycystic Ovary Syndrome Therapeutics and clinical risk management · 2008
    4. Steroid 5α-Reductase Inhibitors Mini-reviews in Medicinal Chemistry · 2003
    5. Androgen Receptor Antagonists Structure-Activity Relationships Current Medicinal Chemistry · 2000
    6. RU 58841, A New Specific Topical Antiandrogen: A Candidate of Choice for the Treatment of Acne, Androgenetic Alopecia, and Hirsutism The Journal of Steroid Biochemistry and Molecular Biology · 1994
    7. Clinical Applications of Antiandrogens Journal of Steroid Biochemistry · 1988