Bicalutamide in Dermatology: A Narrative Review

August 2024 in “ Indian Dermatology Online Journal ”

Vineet Relhan, Arunima Ray, Ishan Agrawal

bicalutamide non-steroidal antiandrogen female pattern hair loss androgen receptors minoxidil spironolactone antiandrogens serum transaminases hypertrichosis FPHL

From the encyclopedia

Bicalutamide →

a nonsteroidal anti-androgen, most commonly used orally for women

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Spironolactone →

powerful topical and oral anti-androgen used mostly by women

Studysummary In this study, bicalutamide showed promise in managing female pattern hair loss and reducing minoxidil-induced hypertrichosis, though further research is necessary to refine its use and establish its role in treatment.

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Research cited in this study

9 / 9 results

research Mesotherapy With Bicalutamide: A New Treatment for Androgenetic Alopecia

January 2023 in “International Journal of Trichology”

This study found that bicalutamide mesotherapy resulted in subtle hair density improvements and was well tolerated by premenopausal women with androgenetic alopecia.

research Comment on Bicalutamide Improves Minoxidil-Induced Hypertrichosis in Female Pattern Hair Loss: A Retrospective Review of 35 Patients

1 citations , March 2022 in “Journal of The American Academy of Dermatology”

This study by Moussa et al. reported that bicalutamide may help reduce minoxidil-induced hypertrichosis in women with female pattern hair loss.

research Bicalutamide and the New Perspectives for Female Pattern Hair Loss Treatment: What Dermatologists Should Know

3 citations , January 2022 in “Journal of Cosmetic Dermatology”

This review highlights bicalutamide as a promising oral therapy for female pattern hair loss, noting its safety, tolerability, and effectiveness in women with hyperandrogenic symptoms like acne and hirsutism, though further trials are needed to confirm its ideal dose and efficacy.

research Bicalutamide Improves Minoxidil-Induced Hypertrichosis in Female Pattern Hair Loss: A Retrospective Review of 35 Patients

4 citations , November 2021 in “Journal of The American Academy of Dermatology”

This article notes that low-dose systemic minoxidil combined with antiandrogen therapy is effective for treating female pattern hair loss, though hypertrichosis can occur in a significant percentage of patients.

research Bicalutamide: A Potential New Oral Antiandrogenic Drug for Female Pattern Hair Loss

8 citations , April 2020 in “Journal of The American Academy of Dermatology”

This article discusses the potential of oral bicalutamide as a promising treatment for female pattern hair loss and reports no new clinical results.

research Safety of Oral Bicalutamide in Female Pattern Hair Loss: A Retrospective Review of 316 Patients

16 citations , March 2020 in “Journal of The American Academy of Dermatology”

This abstract discusses the efficacy of spironolactone, cyproterone acetate, and flutamide in treating female pattern hair loss, noting that flutamide use requires caution due to potential liver toxicity, especially at high doses.

research Oral Bicalutamide for Female Pattern Hair Loss: A Pilot Study

8 citations , October 2019 in “Dermatologic Therapy”

This source explores the potential use of oral bicalutamide for treating female pattern hair loss, but specific results or outcomes from the study are not reported in the abstract.

research Frontal Fibrosing Alopecia After Antiandrogen Hormonal Therapy in a Male Patient

9 citations , January 2018 in “Journal of the European Academy of Dermatology and Venereology”

A male patient developed frontal fibrosing alopecia after antiandrogen therapy for prostate cancer.

Combined Oral Contraception and Bicalutamide in Polycystic Ovary Syndrome and Severe Hirsutism: A Double-Blind Randomized Controlled Trial

research Combined Oral Contraception and Bicalutamide in Polycystic Ovary Syndrome and Severe Hirsutism: A Double-Blind Randomized Controlled Trial

25 citations , December 2017 in “The Journal of Clinical Endocrinology & Metabolism”

This study found that using an oral contraceptive with bicalutamide significantly reduced hirsutism in women with PCOS compared to an oral contraceptive alone, although it increased total cholesterol and LDL levels.