TLDR Bicalutamide mesotherapy may help with hair loss and seborrhea but needs more research.
The study evaluated the use of bicalutamide mesotherapy in six premenopausal women with Olsen Grade II or III androgenetic alopecia and significant seborrhea. Each patient received three monthly sessions of 1 ml bicalutamide 0.5% mixed with 1 ml lidocaine 2%. Results showed a subtle improvement in hair density after the third session, though this did not persist at the 6-month follow-up. Patients reported a decrease in seborrhea and an overall satisfaction score of 6.3 out of 10. The treatment was well-tolerated, suggesting potential as an adjuvant therapy for androgenetic alopecia, but further studies are needed to optimize the treatment protocol.
8 citations
,
April 2020 in “Journal of The American Academy of Dermatology” Bicalutamide may be a promising alternative treatment for female pattern hair loss.
16 citations
,
March 2020 in “Journal of The American Academy of Dermatology” Oral bicalutamide is safe and effective for female hair loss.
5 citations
,
January 2020 in “Skin appendage disorders” Oral dutasteride works better for hair loss, but has more sexual side effects; intralesional dutasteride is a possible alternative.
24 citations
,
January 2017 in “International Journal of Trichology”
17 citations
,
November 2021 in “Journal of Cosmetic Dermatology” Combination therapies for androgenetic alopecia work best but can have significant side effects and costs.
March 2025 in “JAAD reviews.” Bicalutamide can reduce female pattern hair loss, especially in those with certain conditions, but has limited effects on other hair loss types.
1 citations
,
August 2024 in “Indian Dermatology Online Journal” Bicalutamide may effectively treat female pattern hair loss with minimal side effects.
March 2023 in “Anais Brasileiros De Dermatologia” Topical minoxidil is the best-supported treatment for female hair loss, but personalized plans are needed.
June 2023 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Bicalutamide mesotherapy improved hair density in women with hair loss and was well received.
