Comment on Bicalutamide Improves Minoxidil-Induced Hypertrichosis in Female Pattern Hair Loss: A Retrospective Review of 35 Patients

    March 2022 in “ Journal of The American Academy of Dermatology ”
    Ralph M. Trüeb, Ngoc-Nhi Catharina Luu, Hudson Dutra Rezende
    TLDR Adjusting minoxidil dosage may be safer than using bicalutamide for hair loss in women.
    The document discusses a study by Moussa et al. on the use of bicalutamide to mitigate minoxidil-induced hypertrichosis in women with female pattern hair loss (FPHL). The study involved 35 patients and suggested that minoxidil-induced hypertrichosis might be androgen-dependent, challenging the traditional view of it being androgen-independent. However, the commentary raises concerns about the safety of bicalutamide, noting its association with liver toxicity and its contraindication in women who may become pregnant. The commentary also questions the efficacy of antiandrogen treatments for FPHL, suggesting that adjusting minoxidil dosage might be a safer approach.
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