Novel Androgen Receptor Degrader for Androgenetic Alopecia (AGA) Application

April 2023 in “ Journal of Investigative Dermatology ”

C. Chou, C. Liu, P. Liu, P. Cheng, H. Chen, K. Chen, C. Lin

androgen receptor degrader androgenetic alopecia AR protein dihydrotestosterone DHT LNCaP cells topical application finasteride AR degrader AGA Propecia

TLDR A new treatment for hair loss shows promise with fewer side effects.

This study addresses androgenetic alopecia (AGA), a prevalent hair loss disorder, by developing novel androgen receptor (AR) degraders. These degraders specifically target and degrade AR protein, which is implicated in AGA due to increased dihydrotestosterone (DHT) and AR levels. The AR-degrader demonstrated efficacy in LNCaP cells with a low nanomolar DC50 and reversed DHT-induced hair regrowth inhibition in a mouse model. Topical application resulted in minimal systemic absorption, suggesting a lower risk of side effects compared to oral treatments like finasteride. This novel AR-degrader offers a promising, efficient, and safe therapeutic option for AGA.

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