A Semi-Dissolving Microneedle Patch Incorporating TEMPO-Oxidized Bacterial Cellulose Nanofibers for Enhanced Transdermal Delivery

    August 2020 in “ Polymers ”
    Ji Eun Song, Seung‐Hyun Jun, Sun-Gyoo Park, Nae‐Gyu Kang
    TLDR The patch delivers more drugs through the skin effectively.
    The study reported the development of a semi-dissolving microneedle (SDMN) patch incorporating TEMPO-oxidized bacterial cellulose nanofibers (TOBCNs) for enhanced transdermal drug delivery. The SDMN patch featured a two-layer structure with a water-soluble needle layer and an insoluble backing layer containing TOBCNs. This design allowed for effective drug delivery without directly loading drugs into the microneedles. In vitro permeation analysis demonstrated that TOBCNs acted as drug reservoirs, absorbing drug solutions and facilitating their delivery through micro-channels formed by the dissolving needle layer. This method enabled the delivery of larger drug quantities compared to traditional solution application.
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