Nanocomposite Patches for Transdermal Drug Delivery: A Review

Nanocomposite patches for transdermal drug delivery offer a promising solution to overcome the skin's barrier resistance, which limits drug penetration. By integrating biocompatible polymers with nanoparticles, these systems enhance drug transport across the skin, allowing for controlled release and sustained therapeutic levels while minimizing side effects. They improve the delivery of both hydrophobic and hydrophilic drugs, addressing challenges like poor solubility and inconsistent absorption. The versatility of nanocomposites enables customization of drug release profiles, potentially improving patient compliance and therapeutic outcomes. Ongoing research aims to refine these formulations for better efficacy, scalability, and regulatory approval, expanding their clinical applications. The review also covers various nanoparticles and types of transdermal patches, along with their biomedical applications, limitations, and future perspectives.